Maximilian Stötzel

How do embryos and ESCs safeguard pluripotency throughout a state of dormancy? A great collaborative effort of the @bulutkarslioglu -lab & the @MPI_MolGen involving @helenekretzmer @AbhiSampKumar @_taktas_ @VvdWeijden & many more. nature.com/articles/s4159…

1/2 The presence of extraembryonic cells in the developing gut has long puzzled scientists. @BatkiJulia (l) and @hetzel_s (r) (#Meissner lab) now gained new insight into the fate and molecular characteristics of these cells. @NatureCellBio Read more: molgen.mpg.de/4717564/

How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. embopress.org/doi/full/10.10…

Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. rb.gy/spqr9j @NatureCellBio

📢 Preprint! Does the environment of a father before conception influence offspring? Even more, how do paternal genetics & age interact with exposures to affect F1 outcome? We tested this systematically, with intriguing findings & some cautionary tales biorxiv.org/content/10.110…

What a cool surprise on a Friday afternoon - our story on the cover of @NatureSMB. @bulutkarslioglu @MPI_MolGen

🎓Join the @bulutkarslioglu lab & our #IMPRS-BAC #gradschool to solve the key questions at the heart of cellular identity! As a PhD student, you will decipher the crosstalk between gene regulatory layers in #stemcells. #molecularbiology #development 👉 molgen.mpg.de/4644617/Bulut-…

I am so excited to share this part of my PhD where we tackle the question: What impact do 3D contacts have on how enhancers regulate their target genes? biorxiv.org/content/10.110… 1/

A nice video from Fabian Bachinger @VallierLab describing his research on large scale production of hepatocytes for cell based therapy. Thank you @wellcome_leap for supporting us the past 3 years #WellcomeLeap wellcomeleap.org/stories

Honored to receive the @ISSCR Merit Award! It's been a great meeting with inspiring conversations so far!

Human TFs face a molecular trade-off between activity and specificity encoded as submaximal dispersion of aromatic residues in their disordered regions. A collaborative effort of @dhnisz, @VingronLab and Graf Lab published today in @NatureCellBio nature.com/articles/s4155…

The @dhnisz lab with the @VingronLab found chemical features in transcription factors (TFs) that encode submaximal transcriptional activity. The findings in @NatureCellBio hint ways to create optimized TFs that could be used for regenerative therapies. --> molgen.mpg.de/4726976

Humbled & excited that our paper on molecular recording of cellular decision in Trunk-Like Structures (TLS) got featured on the cover of @Dev_Cell! w/ B. Law, M. Chan @Princeton, Z. Smith @Yale, A. Meissner @MPI_MolGen & @jvveenvliet! Link to the paper: cell.com/developmental-…

Great panel discussion on the future of Berlin science with Georg Duda @berlinnovation, @maxplanckpress Vice President @AsifaAkhtar1, Christian Rommel @BayerPharma, and MPIMG Director Alexander Meissner at our #MPIMG60years celebration!