Adriano Bolondi, PhD

Fresh out of the press @Dev_Cell! w Z. Smith @YaleGenetics and B. Law & M. Chan @Princeton we engineer a high-content molecular recorder to reconstruct thousands of cell lineages during embryoid morphogenesis. #MeissnerLab @MPI_MolGen. A🧵(1/14) authors.elsevier.com/sd/article/S15…

We generated a new gastrulation model with somites, spinal cord and a brain-like domain with distinct midbrain and forebrain compartments! How? Gradual assembly + hypoxia!!

Paper Alert !📢Congrats to @StephaRosS & @zaffagg3 on our new review on proteostasis in cellular dormancy. Check out the open-access paper👉sciencedirect.com/science/articl… Lesson learnt: cells know how to chill out and keep things tidy before jumping back into action!👏@CRGenomica

1/ 🚨 Our new paper is online in @Nature ! As its first author, I’m enthusiastic to finally share it with you all!🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 nature.com/articles/s4158… @OxfordDPAG 🧵👇

Thanks for highlighting our work! nature.com/articles/s4158…

Proud to share what we hope will be a reference study on human oocyte proteostasis. Young-donor eggs show globally reduced organelle activity vs. somatic cells, with an even steeper drop as they mature. 👇 for @zaffagg3 's detailed explanation embopress.org/doi/full/10.10…

📣 Paper alert!! Excited to share the 2nd research paper from my time in the @LabBoke at @CRGenomica, out today in the @embojournal! We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?" We collaborated with @DexeusMujer and employed…

Very important piece and missing voice! ISRAELI TARGETING of SCIENTISTS AND UNIVERSITIES IN IRAN AND GAZA MUST ALSO BE CONDEMNED! nature.com/articles/d4158…

There is still some time to secure your spot at the next Niche meeting in CPH. We have a great lineup of speakers! @novonordiskfond @reNEW_Global sciencecluster.dk/event/conferen…

🧬 We're thrilled to close this semester of Reproseminars with Dr. Elvan Böke (@CRGenomica, Barcelona)! 🗣 Talk (in English): "Evading ageing: metabolic and proteostatic adaptations in oocytes" 🗓 Monday 07/07, Special time! 🕐 1 PM ARG🇦🇷 | 12 PM 🇺🇸 East | 6 PM 🇪🇺 Europe Join us!

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. With such a large scope you need excellent partners, so we are happy to have teamed up with @zz_zhaozhang & @VyxPhd nature.com/articles/s4158…

The modularity of the mammalian #embryo in display. Controlled assembly of classic #gastruloids and uncommitted precursors in #hypoxia, patterns the AP axis biorxiv.org/content/10.110… Beautiful from @bulutkarslioglu group. Building to learn! The embryo is a modular structure.

News alert from Bulut-Karslioglu lab! I am very happy to announce that our new study is out in bioRxiv! biorxiv.org/content/10.110… What is new?

It's official - I am thrilled to share that I am joining @MITBiology, the @kochinstitute, and @MIT_IMES as an Assistant Professor this fall! We will be a hybrid lab combining new technologies and computation to study ecDNA and tumor evolution. thejoneslaboratory.com

Check out a technology feature in @Nature by @ElieDolgin regarding our recent 'Killswitch' publication nature.com/articles/d4158… Thank you for the comments and first impressions @youngricka @IsaacAKlein @DanfengCai @SuperSciJew @dhnisz @YZhang1997

Happy Sunday! On my way to Paris to attend the amazing conference "Fertility, contribution of the maternal inheritance" organised by @LabBoke and @MHVerlhac with Fondation @SingerPolignac. But before, as usual the latest papers on #oocyte biology: biomed.news/bims-cebooc/20……

📣PAPER ALERT! 🚨 -> Proteostasis in cellular dormancy: lessons from yeast to oocytes 1/4 Cellular dormancy keeps life "on hold". In our body, dormancy maintains quiescent stem cells and ensures female fertility. How do cells maintain proteostasis during prolonged dormancy? 👇🏼

How do dormant cells keep their proteostasis in check? @zaffagg3 & @StephaRosS take a deep dive in our featured review @TrendsBiochem. Don’t miss it! - EB sciencedirect.com/science/articl…

What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. nature.com/articles/s4158… out now in @Nature with @henri_niskanen @dhnisz & team.