Mara Sherman Lab
@MaraShermanLab
Cancer biologist @MSKCancerCenter
🚨 Our new #preprint is out! doi.org/10.1101/2025.0… We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
Big congrats to @ErnstLengyel and team for this beautiful study linking NNMT in fibroblasts to suppression of antitumor immunity! And exciting results in preclinical models of ovarian cancer 👏🏻👏🏻
🔥 Hot off the press: In a new @Nature study, @ErnstLengyel and team show that blocking NNMT in tumor-supporting cells restores immune response & stops ovarian cancer growth, offering a new strategy for hard to treat cancers. @OvCa_UChicago @uchicago_obgyn ow.ly/zzfZ50Wu3UW
A jobs bonanza from @michiganstateu @HenryFordHealth hiring TEN cancer researchers! henryfordmsu.infoready4.com/#freeformCompe… Applicants focused on pancreas, brain, lung, breast, ovarian, prostate, and hematological cancers are especially encouraged to apply. Please share!
More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…
I'm excited to share the lab’s new paper on PDAC-associated cachexia on bioRxiv today, led by star postdoc @Nikita2106 Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis A 🧵 below, if you're interested... biorxiv.org/content/10.110…
Congratulations to @shouval and all authors for this beautiful and suuuper nicely done study showing a new (and perhaps targetable) way CAFs suppress anti-tumor immunity in breast cancer! 🤩
Thank you @MaraShermanLab for this insightful spotlight on our recent paper in @CD_AACR ! Love the title too 😍 - CAFs Defang NK Cells to Promote Breast Cancer Immunosuppression …crjournals-org.ezproxy.weizmann.ac.il/cancerdiscover…
Behold! From the latest badassery out of the amazing Perera lab, we learn that cholesterol uptake patterns dictate where pancreatic cancer cells seed and grow in the body. Congrats all!! 🤩
Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇
In the Spotlight: FABP4-tastic Pancreatic Stellate Cells Coddle KITL to Uphold Inherent Microenvironmental Tumor Suppression brnw.ch/21wSCgB By Aleksandr Dolskii and @ednacukierman at @FoxChaseCancer
I am thrilled to share that the first preprint from my lab is now available on bioRxiV! In this study, our team elucidates the role of autocrine ligands in the aberrant behavior of oncogene-driven lung cancer. biorxiv.org/content/10.110…
Very excited that our paper on how breast cancer impacts granulopoieses is @Cancer_Cell Fantastic teamwork with the lab of Elzo de Wit @deWitLab spearheaded by talented postdoc @hannah_c_garner (now jr groupleader at McGill) and PhD student @m0rmart @NKI_nl @oncodeinstitute
Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇
Yes! This is another @CD_AACR seminal study by the amazing @MaraShermanLab @MSKCancerCenter and her terrific team & colleagues. Check out this commentary about it by yours truly aacrjournals.org/cancerdiscover…
The final #OpenAccess version of @MaraShermanLab recent paper is now available on @CD_AACR Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression aacrjournals.org/cancerdiscover…
Our latest work, led by @__btjackson and Angela Montero @MSKCancerCenter demonstrates how intracellular metabolic gradients induce dependence on exogenous pyruvate in embryonic stem cells
🤠 👉🏽 🗽 news: I will be joining @nyulangone on September 1, 2025 as Director of the GI Cancer Center & Associate Director of Translational Research at @Perlmutter_CC. I am excited to start the next chapter of the Maitra Lab in NYC & build a strong GI cancer research program.
🔥Smoking hot new paper and tweetorial from @DJCalebC (collab with @ArulChinnaiyan)! 🔥 We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@LyssiotisLab @ArulChinnaiyan), has just been published in @Nature! @UMRogelCancer @UMICHpancreas @UMichMedSchool @UMichPath @UMichResearch @UMichCMB
Welcome to Houston @MaraShermanLab! So glad you could visit the @MDAndersonNews crew. @DrAriaV @ZanivanLab @drgglozano
The final #OpenAccess version of @MaraShermanLab recent paper is now available on @CD_AACR Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression aacrjournals.org/cancerdiscover…
A bright light amid the darkness today - congratulations @Yael_David__ and all authors! Beautiful work, exciting science! ✨
I am extremely proud to see our work about Hepatitis B now published in @CellCellPress. From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 cell.com/cell/fulltext/…
NEW: The Trump administration is exploiting a loophole to keep funding frozen at the NIH - a move that some legal experts say is illegal. Federal Register notices are blocked so no grant-review sessions can be scheduled. All the gritty details in @Nature nature.com/articles/d4158…
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2. The U.S. Senate HELP Committee, run by LA Senator Bill Cassidy has HHS oversight. Call his committee and tell his staff how this Federal Register 'end run' around both Congressional and Court mandates is hurting US Science. Please call his office TOMORROW: 202-224-6770 and
I am so excited to be selected as one of the recipients of the Michelson Prize from the Michelson Medical Research Foundation and the @ImmunomePro! This award enables our lab's research at the intersection of systems immunology, virology, and large-scale genomics research.
Congratulations to Dr. Caleb Lareau, 2024 #MichelsonPrizes recipient! His work will study the blood virome and answer the critical question: how do humans have vastly different responses to the same infection?