Chiara Falcomatà
@ChiaraFalcomata
@CancerResearch postdoc in Brown lab, Icahn School of Medicine at Mount Sinai | pancreatic cancer immunology
Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanINs), in collaboration with @OmicVision @MundAndreas Thousands of proteins from as few as ~100 precisely microdissected cells in archival samples!
🤩Super excited our branched #PancreaticCancer #Organoids to capture tumour heterogeneity made it on the cover of @natBME 🙏🏼nature.com/natbiomedeng/v… @TU_Muenchen @DKTK_ @TUMKlinikum @arispapargyriou @LabReichert
HUGE congratulations to @IamLinghua & team for her latest @Cancer_Cell study Integrative analyses of over 14 million cells from 10 cancer types across 7 spatial transcriptomics and proteomics platforms identifies four distinct spatial CAF subtypes conserved across cancer types
1/ Excited to see moscot-tools.org published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at nature.com/articles/s4158…
More details on 'Bispecific antibody targeting of lipid nanoparticles' in the @biorxivpreprint here >>> biorxiv.org/content/10.110…
First lab tweet! Sharing new papers: PRINT Using Perturb-map, we show how ovarian tumors resist immunotherapy loom.ly/eHXDm4w PREPRINT Developed new technology to easily generate cell-targeted LNP-RNA @SantagataMDPhD @JoshuaBrodyMD @yizhoudonglab
Several years in the making (and aging), @Xueqian_Zhuang 's study on aging is out today @Nature. She finds, surprisingly, that aging suppresses tumorigenesis and stemness in the lung by promoting a functional iron insufficiency in the alveolar epithelium. nature.com/articles/s4158…
So excited to share our new paper out in @Nature led by the fabulous @AnaisElewaut and @guillemxtivill providing mechanistic insights into anti-tumor immunity and why it may fail in so many patients! Sky-torial on @obenaufa.bsky.social rdcu.be/d1F7s
#Immunotherapy has transformed #cancer treatment, but some cancers evade immune defenses, causing resistance. @obenaufa's lab has discovered how inflammatory monocytes—a type of immune cell—can reactivate cancer-killing T cells within tumors. Read more: imp.ac.at/news/article/a…
Very excited to share our latest work on the uncoupling of epithelial regeneration and tumorigenesis in the gut! nature.com/articles/s4158…
New study in @Nature today: Clinical functional proteomics of intercellular signalling in #PancreaticCancer nature.com/articles/s4158… Absolutely stunning amount of cross species spatially and temporally resolved proteomics data in pancreatic cancer. What a resource!
Ovarian cancer-derived IL-4 promotes immunotherapy resistance: Cell cell.com/cell/fulltext/… @IcahnInstitute @IcahnMountSinai @Brown_lab1, Baccarini lab @MiriamMerad @sorger_peter @SantagataLab @DmitriyZamarin @ChiaraFalcomata @JiaRenLin @Nelson_LaMarche .
First of a series of papers from the @NCIHTAN is out in @Nature this morning. Tumour evolution and microenvironment interactions in 2D and 3D space nature.com/articles/s4158…