Mansour Lab
@MansourLab
Lab for Stem Cells, Brain Generation & Degeneration Research @hujimed @hebrewu. We use human stem cell-based technologies to study neurological disorders
Check out our new study published in @CellCellPress.
Very happy and excited to share our paper @CellCellPress. In brief, we developed a human-based, stem cell-derived brain organoid in vivo system for studying neuroinflammatory mechanisms in health and disease @salkinstitute @Hujimed @MedNeuroHUJI cell.com/cell/fulltext/…
Are you passionate about harnessing innovative brain organoid technologies to explore the mysteries of neurodegenerative disorders? Would you like to pursue a Postdoc, MSc or PhD degree in Medical Neuroscience? Join our exciting journey of discovery!
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures: Cell Reports cell.com/cell-reports/f…
Proud of @khamaisi_moran and Amitay Cohen for presenting two talks at the Young Academy of Science and Medicine. Moran was the only undergrad Medical student to be selected to give a talk! Well done, the Mansour lab is proud of you!
A Postdoctoral Research Associate post is available in the lab in Human Organoid Neurobiology and ALS/MND Research - see our job advert in Nature Careers nature.com/naturecareers/…
Our preprint is out nature.com/articles/s4146… In a new set of experiments, we screened a panel of rare and common variants from patients with Autism and identified variants in enhancers of OTX2 & Mir9-2 that reproducibly alter their activity in vivo! Huge congrats to @ewholling
How to test the functional impact of noncoding variants in vivo? Happy to share our work led by @ewholling where we developed dual-enSERT, a new method that enables rapid, quantitative comparison of human enhancer variant activities in live mice. Check this Tweetorial for details
Are you passionate about harnessing innovative brain organoid technologies to explore the mysteries of neurodegenerative disorders? Would you like to pursue an MSc or PhD degree in Medical Neuroscience? Join our exciting journey of discovery!
Excited and relieved to share with you our microglia-sufficient brain organoid work just online @Nature nature.com/articles/s4158… IPSC-derived microglia reprogram them metabolically! And make them mature faster!
I am excited to show you these beautiful movies! A great effort together with @TweetPetrStrnad at @ViventisMicro to design a new #lightsheet for long term high throughput live imaging of large specimens #organoids, #embryoids and entire animals #hydra. dlvr.it/Swnqmw
Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses
We’ve always wondered if there was something beyond CRISPR for genome editing. We now report that animals, plants, fungi and viruses have troves of programmable nucleases capable of efficient gene editing in human cells An update on our Fanzor work! science.org/doi/10.1126/sc… 1/7
3/ Candidates with prior experience in stem cells, tissue culture, microscopy, and/or next-generation sequencing would be an asset. If you are interested, please send your application and CV to: [email protected]. @ERC_Research funded project!
Master’s position has been filled for this year. PhD and Postdoc candidates are welcome to apply!
1/ "Join the Mansour lab at Hebrew University's Dept of Med. Neurobiology! We're recruiting! The Mansour Lab is currently seeking one MS.C., one Ph.D. student, and one postdoc to join our team. @IMRIC_HUJ @MedNeuroHUJI
iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons #ALS #diseasemodeling cell.com/cell-reports/f…
Big Congratulations to our talented 1st undergrad student Moran Khamaisa for being accepted on Fac. of Medicine @Hujimed as a MEDICAL student!! Mabrook and well deserved Moran!
3D segmentation and analysis of cortical mouse #microglia with 3D ImageJ Suite. The free, open source software by Thomas Boudier is available as an ImageJ/FIJI plugin (mcib3d.frama.io/3d-suite-image…).
Thank you, Yanhong Shi & Jonas Cerneckis for this excellent summary of our work! @CellStemCell SPOTLIGHT: hPSC-derived microglia thrive in a humanized brain en... sciencedirect.com/science/articl…
We are recruiting new lab members (Master, PhD and post-doc candidates) for a very exciting (ERC funded) project, designed to unfold the molecular and cellular properties of Brain Barrier cells that mediates the entry of immune cells into the brain.
Biologists trying to create laboratory models of the early growth of a human embryo have taken a major step forward. scim.ag/32S