Pagliarini Lab
@Pagliarini_Lab
Mitochondrial systems biochemistry
💫NEW: @Zak_Bakes @Pagliarini_Lab & co show that #mitochondria stress recovery requires mobilization of #LipidDroplet triacylglycerol stores to facilitate #cardiolipin biosynthesis and mitochondrial biogenesis. nature.com/articles/s4155…
we are excited to share our latest work on mapping and exploiting conditional drug sensitivity in cancer cells @ScienceAdvances! next chapter of unbiased profiling in #HPLM as a source of new insights! congrats to co-1st @kyle_flickinger and Kelli Wilson! science.org/doi/10.1126/sc…
Registration is open (and free) for this year's Midwest Metabolism/Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) Annual Conference at the University of Michigan November 10–11, 2025. Hope to see you there! vai.org/event/2025-mid…
Very proud of the hard work and resilience by @EdreesRashan, @AbbyBartlett_ and many others on this work!
As promised, a 🧵 on our recent article now out in @NatureSMB! Co-led with @AbbyBartlett_ @Pagliarini_Lab @JudithSimcox, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯#lipidtime doi.org/10.1038/s41594…
AHH!! My primary thesis work is finally out! Tweetorial to come...
New online! ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism bit.ly/4kNfh4m
The countdown to #ASBMB25 is on! Visit our annual meeting website to start adding special sessions, keynote lectures, scientific symposia and more to your personal schedule. Plus, check out these other opportunities for scientists: ow.ly/EKcB50VufhH.
ATTENTION #Mito Sci-Med Community: Abstracts for #MitoMed 2025 in St. Louis are due on March 31. Submit your abstract here: umdfconference.org/abstract-submi… Scholarship applications are available on umdfconference.org #mitoresearch #mitomedicine @mitowomen
NIH cuts are hitting young scientists the hardest. By David Baker. timmermanreport.com/2025/03/david-…
🚨New preprint available! Third and final in the #CRISPR screen series!🚨 👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis biorxiv.org/content/10.110… By A. Strefeler in collaboration with @Pagliarini_Lab Please RT 🙏🏻 🧵1/9
🚨 New paper alert! 🚨 Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with @MazeInBiotech 🔗 Paper: doi.org/10.1016/j.cell… @CellCellPress
Join us for the @UMDF Mito Med 2025 meeting this July in St. Louis! Abstract submissions due 3/31. Multiple SciMed Scholarships are being offered this year. See links below! umdfconference.org umdf.smapply.org/prog/2025poste… surveymonkey.com/r/SciMedSchola…
#ASBMB25 is an opportunity to immerse yourself in the forefront of science, exchange groundbreaking ideas, and spark collaborations that could change everything. 🔬You can register and submit your late-breaking abstracts here: bit.ly/3YGLQIx.
Excited to co-chair #ASBMB2025 with the incredible @Pagliarini_Lab! This year’s @ASBMB meeting promises to showcase cutting-edge science, foster dynamic collaborations, & inspire new ideas. Don’t miss your chance to be part of it—register & submit your late breaking abstracts!🔬
#ASBMB25 is an opportunity to immerse yourself in the forefront of science, exchange groundbreaking ideas, and spark collaborations that could change everything. 🔬You can register and submit your late-breaking abstracts here: bit.ly/3YGLQIx.
I'm excited to share our latest work linking TAG mobilization to mitochondrial stress recovery. A monumental effort by @Zak_Bakes (on the faculty job market soon!). Great collaboration with the @Coon_Labs and others. rdcu.be/d5ACF #mitochondria #HHMINews
HHMI Investigator Nels Elde (@ElEarlyBird) of @UUtah works at the crossroads of evolutionary genetics and cell biology to study one of the biggest battlefronts in science: host-pathogen interactions. Learn more about the Elde lab’s research: hhmi.news/49MaU4W
@Pagliarini_Lab we are looking forward to your presentation at #Mito25 this coming February☀️There is only 2 WEEKS left to register, so please RT to let your followers know limited spaces remain to join us in the Dominican Republic! 🇩🇴 Register here➡️bit.ly/3zPBufN
Interested in building small molecule screening and/or genetic assay systems for exploring new mitochondrial biology and therapeutics? See our HHMI posting for a Research Specialist II position. hhmi.wd1.myworkdayjobs.com/External/job/W… #HHMI
Meet our #MitoMed 2025 Planning Committee! Save the Date for our UMDF Mitochondrial Medicine Conference in St. Louis, June 18-21, 2025. Learn more at umdfconference.org
Great as always to work with @taylorlabncl and @MitoMonika! Another interesting example of coordinated coenzyme Q biosynthesis and complex I assembly.
Excited to share our latest preprint, led by @MitoMonika Rachel Guerra & @mitocollier in collaboration with the Wittig lab & @Pagliarini_Lab biorxiv.org/cgi/content/sh…
Researcher at @Coon_Labs @sinitcynlab @PatrickForny @Pagliarini_Lab @Morgridge_Inst apply new mass spectrometer technology to detect and quantify tens of thousands of protein phosphorylation sites within one hour or less of analysis nature.com/articles/s4146…