LukeGilbert

Excited to see the Virtual Cell competition hosted by Arc Institute. We cant "wet lab" our way through the entire matrix of genes x cell types x environments of interest in biology. Cell state models will accelerate progress. x.com/arcinstitute/s…

Today, Arc announced it is joining forces with @NVIDIAHealth to develop powerful computational tools that will help researchers everywhere explore and understand living systems in ways previously impossible. arcinstitute.org/news/news/arc-…

excited about therapeutic biology? consider joining us! job-boards.greenhouse.io/arcinstitute/j…

Want to start your own lab out of grad school? Our Science Fellow program gives you a springboard to launch your independent career! arcinstitute.org/programs/scien… As a Science Fellow, you’ll enjoy: 💸Unrestricted funding to support your research and a team of 2-4 people 🧪Freedom to…

In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…

excited to share COMET! A scalable CRISPR approach we (@carwils) developed to identify multidomain proteins that modulate transcription at specific endogenous genomic loci. @arcinstitute @ucsf doi.org/10.1101/2024.1…

💡Arc was founded so that brilliant minds can pursue their boldest ideas. Announcing the newest Investigators and Awardees joining the Arc community! These exceptional scientists are pioneering research into critical questions about complex human disease. Welcome to: 🧑‍🔬Core…

Happy to report our platform for functional interrogation of cancer and microenvironment cells! Another step toward better treatments for glioblastoma. genomebiology.biomedcentral.com/articles/10.11… @LukeGilbertSF @LabRaleigh @arcinstitute @NeurosurgUCSF

🛠️New CRISPRi tool in @NatureBiotech from @LukeGilbertSF + lab! Until now, scientists have been limited to targeting fewer than 3 genes at a time with CRISPRi. But what about when we want to study more complex combinatorial biology?👇

Check out open Arc Institute Core Investigator and Science Fellows positions! The Core Investigator searches are in partnership with Stanford DBDS, Stanford Department of Pathology and Stanford Department of Genetics.

This week, @MylliaBio welcomed @LukeGilbertSF from the @UCSF and Christoph Bock from the @BockLab at @CeMM_News for the annual SAB meeting in Vienna, Austria! The day was focused on Myllia’s technology platform combining CRISPR perturbation with single-cell RNA sequencing.

We’re thrilled to welcome Hani Goodarzi @genophoria, Associate Professor of Biochemistry & Biophysics @UCSF, as our newest Core Investigator His groundbreaking research uses machine learning models and experimental frameworks to dig into cancer progression and metastasis.

@zhou_jingtian joins as our first Science Fellow. Jingtian is a recent PhD graduate in Bioinformatics & Systems Biology from @UCSD and a former Salk Institute scientist. His pioneering work has developed new algorithms and insights into the epigenetic basis of brain development

We’re honored to be on the @endpts #Endpoints11 2023 list of the most promising biotechs alongside an outstanding group of peers at the forefront of drug development. Cheers to our world-class cofounders, investors and partners, and dedicated team. More: chromamedicine.com/2023/09/21/chr…

Excited to share our (with @LukeGilbertSF) new preprint (is.gd/5kgWsI) on a new combinatorial functional genomics platform that enables 6-plex CRISPRi pooled screens. This platform works for multi-gene targeting and is especially suited for multi-enhancer targeting.

excited about multiAsCas12a which we (@hsiung_chris) show enables 6plex CRISPRi functional genomics experiments @arcinstitute @ucsf doi.org/10.1101/2023.0…

In vivo perturb-seq in cancer and immune cells with @sjohnliu and @LabRaleigh. doi.org/10.1101/2023.0… Excited for this kind of approach in adult tissues and diseases! @arcinstitute @ucsf

Excited to share our work on how environmental perturbation rewires functional connection between human genes. @ucsf @arcinstitute doi.org/10.1101/2023.0…

Excited to share our work identifying IFITM proteins as key for cellular uptake of large drugs that break standard drug design rules! Hope it leads to new drug designs! This was a wonderful collaboration with @kevansf led by Kevin Lou @ucsf @arcinstitute science.org/doi/10.1126/sc…

Come join our team at Arc Institute! We are hiring a Scientist/Sr Scientist for an in vivo functional genomics role, a lab manager and postdoctoral fellows. Email me or: Scientist/Sr Scientist boards.greenhouse.io/arcinstitute/j… Lab Manager boards.greenhouse.io/arcinstitute/j…