Kuchroo Lab
@KuchrooLab
Lab of Prof. Vijay Kuchroo @GeneLayInst @BrighamWomens @HarvardMed @BroadInstitute. Posts by lab members unless signed by VKK. Views are our own.
Our annual symposium on Immunity & Inflammation in Disease & Tissue is on again – August 6th at the Joseph B. Martin Conference Center, Boston MA. Looking forward to talks from @RafiAhmed_Lab, Richard @FlavellLab, @ElaineFuchsLab, #BanaJabri & @LarrySteinman.
Last chance to save on registration for #CSNeuroimmune25 – Sept 7–9 in NYC. Join leading voices in #neuroimmunology including David Julius & Susan Kaech. Explore the neuro-immune axis in inflammation, cancer & more. hubs.li/Q03t-gD50
#RTN2025
Have you registered yet for #ReThinkNeuroimmunology in October? Organizers, @QuintanaLabHMS @Stevens1Lab @JonyKipnis @IdoAmitLab @RejaneRua have put together stellar program for the 3-day event. #RTN Register here:🔗genelayinstitute.org/rtn/
And just like that - @BrighamWomens internal medicine residency ✅ laughter, tears, diet ginger ale, the greatest co-residents and my incredible family who supported me and raised my kids so I could be here today. It takes a village - and I have the best one ❤️ @BrighamMedRes
Happy to share that this study led by @TheNeuroImmLab Allon Wagner & Johannes Fessler, in collaboration with @YosefLab, is now published @CellReports. We uncover that the glycolytic enzyme, PGAM, suppresses Th17 pathogenicity & autoimmunity cell.com/cell-reports/f…
Not all glycolytic enzymes promote Th17 cell pathogenicity. Our study shows that phosphoglycerate mutase (PGAM) is a key metabolic regulator suppressing Th17 cell pathogenicity in vivo. Read more in our preprint 👇with @TheNeuroImmLab @YosefLab biorxiv.org/content/10.110…
The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity @CellReports @nir_yosef1 @KuchrooLab cell.com/cell-reports/f…
NPR story on 1st AD pt. Rx w/nasal foralumab shorturl.at/ba16d Moderate AD- not eligible for lecanemab. Expanded access Rx. Tolerating it well. To begin controlled trial at BWH in mild AD. Lost my mom to AD who asked “Howie, can you help me?” I couldn’t then, but could now.
What a huge effort from grad student @RockyBarilla who was responsible for driving this project. Well done to Rocky & everyone involved.
🚨New paper with @TheXavierLab @ScienceMagazine on the critical role of 🔁neuroimmune crosstalk in immune defense in the gut! @GeneLayInst @MGBResearchNews @HarvardMed @BroadInstitute science.org/doi/10.1126/sc…
(1/6) Exciting! Our latest paper in @cellhostmicrobe shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway. cell.com/cell-host-micr…
Out now in @Science! We and the @KuchrooLab described responses of enteric neurons to inflammatory cues during infection, showing that primary sensory neurons detect type 2 cytokines, balance neuropeptides, and influence site-specific immunity. science.org/doi/10.1126/sc…
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense science.org/doi/10.1126/sc… @ScienceMagazine @RockyBarilla @KuchrooLab @TheXavierLab
Kudos to Francisco and the @QuintanaLabHMS on this beautiful work. Glioblastoma-instructed astrocytes suppress tumor-specific T cell immunity.
Our study on glioblastoma-associated immunoregulatory astrocytes is out in @Nature today by @CamiloFaustAkl! We identified GBM-derived IL-11 as a regulator of TRAIL+ astrocytes, which limit anti-tumor T cell responses via apoptosis. nature.com/articles/s4158…
So great that Brenda & Jason gave us daily recaps of their favorite talks at #AAI2025 @ImmunoPodcast. This episode features a talk by Ana Anderson @AnaAndersonlab on how opioids drive immunosuppression in T cells in cancer. Hear about this & more👇
📣 Our last #IMMUNOLOGY2025 episode is out now! Catch up on the final day of the meeting: bit.ly/4kdW2Al #AAI2025
The lab family are also thrilled!🙌
Congrats Dad @KuchrooLab on your meritorious career award for contributions to the field including #TIM3 & #Th17 cells. Your discoveries have created therapeutics that have shaped our approach to cancer and autoimmunity. Thanks to @ImmunologyAAI & @thermofisher for this moment
Our research on how the immune checkpoint TIM-3 regulates microglia & Alzheimer's disease highlighted in the @Harvard Gazette. news.harvard.edu/gazette/story/…
Congratulations @mwheeler0 et al. on this elegant study showing the underlying mechanisms of how psychedelics influence neuroimmune interactions with implications for fear behaviour. Delighted to be able to contribute to this work. nature.com/articles/s4158…
Researchers @GeneLayInst show that psychedelic compounds regulate neuroimmune interactions to control stress-induced fear. Study from Michael Wheeler’s (@mwheeler0) lab, now published @Nature. @MGBResearchNews @harvardmed
Nature research paper: Psychedelic control of neuroimmune interactions governing fear go.nature.com/4izW8kH
Wow, wow, wow! Psychedelic control of neuroimmune interactions governing fear #psychedelics nature.com/articles/s4158…