Fran Quintana Lab
@QuintanaLabHMS
Our goal is to combine advanced tools with innovative experimental models to study neuroinflammatory disorders and cancer. Tweets by lab members
Our Nature Protocol for SPEAC-seq is out today! Hoping to see more labs implement this scalable platform for functional CRISPR screening of cell-cell interactions @CamiloFaustAkl nature.com/articles/s4159…
Interested in working cancer immunotherapy research? The Andersen lab is looking for a Research Assistant to work on glioblastoma. More information below:
Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in @Nature today! Congrats to Brian Andersen and @CamiloFaustAkl! nature.com/articles/s4158…
New pre-print from our lab here: biorxiv.org/content/10.110…
Therapeutic B cell depletion identifies immunoregulatory networks preview @jclinicalinvest @QuintanaLabHMS @carol_zinhap jci.org/articles/view/… article @DavidHaflerMD @ppaxisa jci.org/articles/view/…
Our study on glioblastoma-associated immunoregulatory astrocytes is out in @Nature today by @CamiloFaustAkl! We identified GBM-derived IL-11 as a regulator of TRAIL+ astrocytes, which limit anti-tumor T cell responses via apoptosis. nature.com/articles/s4158…
Nature research paper: Psychedelic control of neuroimmune interactions governing fear go.nature.com/4izW8kH
New review on our all-time favorite molecule out today in @NatRevDrugDisc by @carol_zinhap!
The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation nature.com/articles/s4157… This new review discusses how the AHR - once avoided in drug development - is now being targeted for inflammatory disorders, cancer and infectious diseases
A genome-wide CRISPR screen for regulators of astrocyte inflammation identified CLEC16A, linked to MS susceptibility, as a suppressor of NF-κB signaling; CLEC16A promotes mitophagy, and ablating it in astrocytes worsens pathology in an MS model nature.com/articles/s4159…
Our study on the protective role of CLEC16A in astrocytes in MS is out today in @NatureNeuro! Congrats to Atsushi and all collaborators! nature.com/articles/s4159…
A tour de force review of the connections between the nervous and immune systems @Nature nature.com/articles/s4158… @QuintanaLabHMS
Today we all dressed up as our favorite and most consistently dressed scientist: @hong_lee89 Happy Hongloween! 🎃👻
#NewNProt describing a #microfluidic-based platform to study #cellcellinteractions bit.ly/4eM1WG4 @QuintanaLabHMS
Host-gut microbiota crosstalk predicts neuroinflammation - A quick read News and Views by @QuintanaLabHMS. nature.com/articles/s4156…
Yearly lab race: complete! Quintana lab rats zoomed through the @racecancer 5K yesterday, with an unlikely winner taking the first place 🏆 Next up - lab olympics?
Great paper identifying a mechanism of inflammation-induced neurodegeneration in MS! Check out the preview written by @hong_lee89 doi.org/10.1016/j.molc…
Now online! STING orchestrates the neuronal inflammatory stress response in multiple sclerosis dlvr.it/T8HhbT
Congrats to @MiKilian90 for making the cover of @SciImmunology! This exciting story on NK cell-mediated lysis of activated T cells via B7H6 proposes a potential checkpoint mechanism for cancer immunotherapies
Natural killer cells lyse #Tcells that express #B7H6 protein, restricting #antitumor #CART response in mice, according to a new study. @broadinstitute @Platten_lab @DKFZ Learn more: scim.ag/6PJ
Nature research paper: Disease-associated astrocyte epigenetic memory promotes CNS pathology go.nature.com/3Tp21q7
Congratulations to @hong_lee89 for his study out today in @Nature! We describe epigenetic memory in ACLY+p300+ astrocytes that worsens MS pathology nature.com/articles/s4158…
Thanks for the kind words @JoonHyukLee3! bwhclinicalandresearchnews.org/2024/02/01/men…