Jens Hör

@Jens_Hoer

Molecular Principles of RNA Phages Junior Professor @Uni_WUE Group Leader @Helmholtz_HIRI

Würzburg, Germany

Joined April 2010

304Following

629Followers

Pinned

Jens Hör@Jens_Hoer · Jul 17, 2024

Thrilled to share the final version of my postdoc project, out today in @Nature! We investigated the Bil system – a ubiquitin-like antiphage defense system – and discovered a new defense mechanism! More info in the thread below 👇 nature.com/articles/s4158…

Jens_Hoer's tweet card. Nature - To mitigate phage infection, an antiphage defence system in bacteria conjugates a ubiquitin-like protein to a structural protein of the phage, demonstrating that conjugation of...

106

389

39.0K

Pinned

Jens Hör Retweeted

Rafa Pinilla-Redondo@rafapinilla92 · Nov 5

🧬🧬 𝙉𝙚𝙬 𝙋𝙧𝙚𝙥𝙧𝙞𝙣𝙩!!🧬🧬 Latest collab with the amazing Ming Li & Yue Feng labs! How do phages bypass multi-layered defenses in bacteria? Spoiler: with equally complex anti-defenses!! 🧵👇 biorxiv.org/content/10.110…

120

9.0K

Jens Hör@Jens_Hoer · Jan 21

I'm excited to present my work at the IIMCB in Warsaw! Details and a Zoom link below 👇

IIIMCB, Warsaw, Poland@IIMCB_Poland · Jan 21

We are pleased to invite you to the upcoming scientific seminar by @Jens_Hoer 🗓️23.01.2025 🕘09:15 AM CET 💻Join us on Zoom: bit.ly/3NxdIbY #IIMCBseminar #IIMCBonlineSeminarSeries

746

Jens Hör Retweeted

Itai Yanai@ItaiYanai · Nov 13

I’ve met so many amazing people here but it’s clearly time to go. I hope you’ll consider joining us at the Other Place now to rebuild our community.

4.0K

Jens Hör Retweeted

Henriques-Normark lab@BHN_Lab · Nov 12

Excited to share our recent review on S. pneumoniae in @NatureRevMicro nature.com/articles/s4157…

660

Jens Hör@Jens_Hoer · Nov 11

If you want to find me where the sky is blue, see below 👇

560

Jens Hör Retweeted

Kotaro Kiga@KotaroKiga · Nov 11

Phage vs. Bacteria: New findings! Phages use their own tRNAs to evade bacterial defenses like retrons and PrrC. Huge thanks to Azam for his hard work! in @NatureComms nature.com/articles/s4146…

132

8.0K

Jens Hör Retweeted

Helmholtz Institute Würzburg (HIRI)@Helmholtz_HIRI · Nov 7

Interested in phage therapy? TWINCORE is hosting a mini-symposium on these “microbe eaters” & their role in infection research & medicine on November 13. Speakers include @Jens_Hoer & @Milan_Gerovac. Guests are welcome, and registration is not required! twincore.de/en/events/news…

537

Jens Hör Retweeted

Milan Gerovac@Milan_Gerovac · Nov 5

Exciting news! I started the junior research group 'Complexes in Phage-infected Cells' at Helmholtz Centre for Infection research @Helmholtz_HZI looking forward to explore new jumbo phage biology. We’re hiring! Join us for a PhD position.

157

13.0K

Jens Hör@Jens_Hoer · Nov 5

This is a very important study! Congrats to all authors 👏

MMDMLab@MDMlab_Paris · Nov 5

Out @NatureMicrobiol, we predicted phage-bacteria interactions in E. coli species using only genomic information. Adsorption, not defense systems, is the main driver at this scale (relevant for a phage therapy context), leading to tailored cocktails! nature.com/articles/s4156… 🧵👇

1.0K

Jens Hör Retweeted

Iana Fedorova@femtokot · Oct 31

I am very proud to share our paper on Tad1/Tad2 sponges, which appeared to be multifunctional anti-defense proteins that inhibit many different signaling-based immunity systems!💫 nature.com/articles/s4158…

18.0K

Jens Hör@Jens_Hoer · Nov 1

🚨New preprint from our lab! We map the RNA interactions in E. coli infected by lambda, revealing an RNA-driven regulatory layer in phage-host dynamics. We find a phage-encoded sRNA hijacking host replication machinery, impacting the phage cycle.#microbiology #phages @MeetingRna

bbioRxiv Microbiology@biorxiv_micrbio · Nov 1

Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle biorxiv.org/cgi/content/sh… #biorxiv_micrbio

8.0K

Jens Hör Retweeted

Helmholtz-Zentrum für Infektionsforschung –inaktiv@Helmholtz_HZI · Oct 30

#Bakteriophagen gelten als mögliche Alternative zu klassischen Antibiotika. Ein Minisymposium am @TWINCOREtweets am 13. November beschäftigt sich mit der Rolle von Phagen in Infektionsforschung und Medizin. Mit dabei sind u.a. @Milan_Gerovac & @Jens_Hoer. twincore.de/en/events/news…

639

Jens Hör Retweeted

Sorek Lab@SorekLab · Oct 30

Fancy a postdoc in Munich? For a collaborative project between @SorekLab and @hornung_lab on antiviral innate immunity, we are looking for exceptional candidates with skills in immunology / biochemistry / computational biology. More details here: genzentrum.uni-muenchen.de/career/postdoc…

12.0K

Jens Hör@Jens_Hoer · Oct 29

1/5 Big news from Aguilar Lab! Check out our first preprint! We’ve developed a new prostate organoid model to crack the mystery of E. coli prostatitis, a common, tough-to-treat infection in men. Our model reveals how these bacteria get in and thrive. #UPEC #Organoids #UTI

bbioRxiv Molecular Biology@biorxiv_molbio · Oct 29

Prostate-specific membrane receptor PPAP facilitates E. coli invasion of luminal prostate cells via FimH binding biorxiv.org/cgi/content/sh… #biorxiv_molbio

5.0K

Jens Hör@Jens_Hoer · Oct 28

I am excited to finally share this preprint from @JoergLab. We've developed a reporter assay to enable high throughput discovery of carriers for ASOs into bacteria. This was a challenging and exciting journey for me, from MedChem/ChemBio into Mol/SynBio.

bbioRxiv Microbiology@biorxiv_micrbio · Oct 26

RNA toehold switch-based reporter assay to assess bacterial uptake of antisense oligomers biorxiv.org/cgi/content/sh… #biorxiv_micrbio

3.0K

Jens Hör Retweeted

Ewelina Malecka@EMaleckaPhD · Oct 29

Received some wise words from the incredible Katalin Karikó today @EMBO! A reminder to dream big, work with joy, and be careful with your RNA in the lab :) #EMBOat60

4.0K

Jens Hör Retweeted

Joe Bondy-Denomy@joeBondyDenomy · Oct 28

Did you know that bacteria remember their past for many generations? In this new preprint from us (@VillaniAlexis and Senen Mendoza) and Banin lab (@ShmidovE ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. biorxiv.org/content/10.110…

163

18.0K

Jens Hör Retweeted

Sorek Lab@SorekLab · Oct 25

We discovered a new immune signaling molecule: N7-cADPR N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection Preprint: biorxiv.org/cgi/content/sh… Congrats @FrancoisRousset & @IlyaOsterman

100

309

50.0K

Jens Hör@Jens_Hoer · Oct 28

Such a nice study! Congrats @FrancoisRousset and @IlyaOsterman!! 👏

bbioRxiv Microbiology@biorxiv_micrbio · Oct 26

RNA toehold switch-based reporter assay to assess bacterial uptake of antisense oligomers biorxiv.org/cgi/content/sh… #biorxiv_micrbio

546

Jens Hör Retweeted

Dor Salomon@DrDorSalomon · Oct 23

Happy to share our work in @NatureMicrobiol. Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. If you're interested in #Antiphage #T6SS #Vibrio #MGE then this is for you. 🧵1/15 rdcu.be/dXMwQ nature.com/articles/s4156…

136

12.0K