MDMLab
@MDMlab_Paris
Molecular Diversity of Microbes Lab @institutpasteur // Focusing on bacterial immunity 🦠🧬🧫 // We ♥️ sharing our science with everyone // PI @AudeBer
Out in @cellhostmicrobe: Conservation of antiviral systems across domains of life reveals immune genes in humans. Using phylogenomics, we traced antiphage systems in eukaryotes, predicted human homologs and validated their immune function in human cells! cell.com/cell-host-micr…
This is a very important study! Congrats to all authors 👏
Out @NatureMicrobiol, we predicted phage-bacteria interactions in E. coli species using only genomic information. Adsorption, not defense systems, is the main driver at this scale (relevant for a phage therapy context), leading to tailored cocktails! nature.com/articles/s4156… 🧵👇
I am very proud to share our paper on Tad1/Tad2 sponges, which appeared to be multifunctional anti-defense proteins that inhibit many different signaling-based immunity systems!💫 nature.com/articles/s4158…
OUT NOW 🦠 Prediction of strain level phage-host interactions across the Escherichia genus using only genomic information, by @AudeBer @hugovaysset @MDMlab_Paris @iame_center @PhagePasteur nature.com/articles/s4156…
We discovered a new immune signaling molecule: N7-cADPR N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection Preprint: biorxiv.org/cgi/content/sh… Congrats @FrancoisRousset & @IlyaOsterman
Our NAD-reconstitution story is finally published in @nature rdcu.be/dU5AQ Thank you to all co-authors, especially to @hadarsamra, @FrancoisRousset, Elena Loseva, @ErezTzvi, @AdiMillman, and everybody in the @SorekLab for their help and support.
"Little pigeons can carry great messages🕊️" Phages produce NAD+ by one-step reactions from nicotinamide (all other organisms need at least two) and protect themselves against multiple bacterial immune systems. Check out our new preprint - biorxiv.org/content/10.110… A thread below⬇️