Joschka Hey
@HeyJosch
Data-driven scientist | from confusion to understanding @[email protected]
I am happy to share that @NatureComms has published our latest research from the @DKFZ. DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts Here’s the link to the article: nature.com/articles/s4146… 👇 1/7
Ashish Goyal, Jens Bauer und Joschka Hey erhalten den diesjährigen #WaltraudLewenzPreis für ihre Arbeit über die Identifizierung von Neoantigenen, die von neu aktivierten Transkripten bei epigenetischen Therapien kodiert werden. Herzlichen Glückwunsch! 👏 @DKTK_
Trackplot: a fast and minimal dependency R script for epigenomic enrichment plots academic.oup.com/bioinformatics… github.com/PoisonAlien/tr…
Congratulations to all authors involved in this beautiful study about Juvenile Myelomonocytic Leukemia! I am pleased to have contributed to this work that not only demonstrates the oncofetal reprogramming of this childhood cancer, but also identifies therapeutic vulnerabilities.
Exciting findings in #childhoodcancer #oncofetal reprogramming of postnatal #stemcells and CD52 as a novel therapeutic target in #pediatric #leukemia New preprint from our lab by @mp_hartmann @MaxSchoenung @dblipka1 biorxiv.org/content/10.110…
Epigenetisch wirkende Medikamente ermöglichen, dass Bereiche des Erbguts abgelesen werden, die vorher blockiert waren. Das führt zur Bildung neuer mRNA und neuer Proteine, die das Immunsystem beim Erkennen von Krebszellen unterstützen könnten. @uktuebingen t1p.de/994hd
One in 400 people among the general population – and 1 in 40 Ashkenazi Jews – is born with mutations in the BRCA genes that increase the risk of several cancer types. It's not surprising then that these mutations keep cancer researchers busy. (1/3)
Very happy that this is out! Thanks to the work of many passionate scientists from Academia, Industry and Clinics, to the generosity of #COPDpatients. High-resolution #transcriptomic and #epigenetic profiling ids novel #COPD regulators #Multiomics #humanLungFibroblasts
We completed the first whole genome #DNAmethylation profiles in #copd, revealing potential disease regulators 👇. High‐resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD embopress.org/doi/10.15252/e… #epigenetics, #wgbs 🧵
We completed the first whole genome #DNAmethylation profiles in #copd, revealing potential disease regulators 👇. High‐resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD embopress.org/doi/10.15252/e… #epigenetics, #wgbs 🧵
Delighted to share our story about enhancer hijacking event! First contributing article of my PhD @DKFZ . Many more to come hopefully 😉 @Nature nature.com/articles/s4137…
🔥📢Read the new study led by our very own Editor-in-Chief C. Plass @DKFZ and R. Scherz-Shourval @WeizmannScience on the epigenetic reprogramming of #TumorAssociatedMacrophages and their #DNAmethylation landscape 🔓➡️doi.org/10.1002/ijc.34… #breastcancer, #TumorMicroenvironment
Have you ever asked yourself how myeloid cells are reprogrammed to become tumor-associated macrophages (TAMs)? Our recent publication @IntJCanc indicates a prominent role of DNA methylation in the epigenetic reprogramming of TAMs! onlinelibrary.wiley.com/doi/10.1002/ij… 1/n