Translational Cancer Epigenomics
@TransCanEpi
Official account Section Translational Cancer Epigenomics @TMO_Heidelberg @NCT_HD @DKFZ, #epigenomics, #hematopoiesis, #JMML, #singleCell, #precisiononcology
Exciting findings in #childhoodcancer #oncofetal reprogramming of postnatal #stemcells and CD52 as a novel therapeutic target in #pediatric #leukemia New preprint from our lab by @mp_hartmann @MaxSchoenung @dblipka1 biorxiv.org/content/10.110…
Our 'EPINUC' liquid biopsy technology, advanced and tailored for diagnosis and monitoring of pediatric gliomas. A joint work with our FANTASTIC collaborators @CarlKoschmann @KoschmannLab @vennetilab biorxiv.org/content/10.110…
Our work on aberrant MNX1 expression in AML caused by enhancer hijacking is finally out! Great collaboration between the Plass lab, @TransCanEpi and many others! Thanks a lot to everyone involved! 🙋🏻♂️
Enhancer hijacking discovery in acute myeloid leukemia by pyjacker identifies MNX1 activation via deletion 7q: brnw.ch/21wRWqT
We are hiring! For our Translational Cancer Epigenomics team @DKFZ and @NCT_HD we are looking for a talented postdoc interested in research on heme malignancies and #epigenetics. 🧬🧪🩸 Interested? 👉See jobs.dkfz.de/en/jobs/167620… or DM me!
Excited to announce the upcoming 80th Heidelberg Grand Round on "Developmental Signatures and Molecular Plasticity in Cancer"! Join us in Heidelberg, on Nov 14, 2024, from 4:00-6:00 PM–free of charge! Explore #Cancer as a developmental disease! @DKFZ @NCT_HD @uniklinik_hd
This collaborative effort demonstrates that ectopic expression of MNX1 is a driver event in a subset of adult del(7q) AML. #AML #leukemia #epigenomics
I'm excited to share our preprint "Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q": doi.org/10.1101/2024.0…. This is my main PhD work and a massive collaborative effort. 🧵👇
I'm excited to share our preprint "Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q": doi.org/10.1101/2024.0…. This is my main PhD work and a massive collaborative effort. 🧵👇
POSTDOC OPPORTUNITY TO JOIN US! Are you interested in how nuclear metabolism impacts on chromatin function and gene regulation in leukemia? Apply for an attractive postdoc position with us through the MSCA @carrerasleaders program! More info here: buschbecklab.org/join-us/
Looking for a #postdoc in #epigenomics and #CancerResearch ? 👉Maybe this opportunity @DKFZ is right for you! Application deadline is Sept 15th! dkfz.de/en/postdoc-pro…
Interesting method for #singlecell transcriptomic analysis of rare cell types: biorxiv.org/content/10.110…
Monday March 4, 16.00 CET Virtual Erasmus Hematology Lecture Daniel Matson , University of Wisconsin with: "Linking GATA2 to myeloid dysplasia and complex cytogenetics in adult myelodysplastic neoplasm and acute myeloid leukemia" Link: us06web.zoom.us/j/83009472100 @danielmatsonlab
We are looking for a motivated #postdoc with experience in #CRISPR and #mousemodels. Join us at our new lab @uniklinik_hd, @KITZ_HD to study #acuteleukemia vulnerabilities. More details: karriere.klinikum.uni-heidelberg.de/index.php?ac=j…
Today @MariamHakobya20 successfully defended her PhD thesis with a stellar presentation! 💪🏻🥳💐🎉Huge congrats and very well deserved Dr. Hakobyan!🎓 @TransCanEpi @DKFZ
Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions dlvr.it/T16fGz
Please read our new precision #RareCancer medicine study, which we hope will help improve outcomes for patients with a peculiar #Sarcoma subtype that lacks effective systemic therapies. nature.com/articles/s4146…
I'm excited to share our preprint "Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q": doi.org/10.1101/2024.0…. This is my main PhD work and a massive collaborative effort. 🧵👇
Our single cell analysis of MLL/KMT2A fusions in AML with Michael Lübbert's group @Uniklinik_Fr is now out in @BloodAdvances. It shows a progenitor-like phenotype of the novel MLL-EDC4 fusion. Free download link: authors.elsevier.com/sd/article/S24…. Thanks to DFG FOR2674 for support.
Very proud of our study in Blood (+cover and editorial) led by @sarahelitzur and @Ruthyshioh describing a novel non-canonical MAPK activation pathway leading to histiocytosis, in patients with H syndrome. From bed to bench and back to bedside. ncbi.nlm.nih.gov/pubmed/37738562
Very interesting work suggesting a model for epigenetic memory. #epigenetics #epigenomics
3/4 Epigenetic memory is stored differently through the cell cycle: Interphase - the memory is in folding of dense heterochromatin condensate – marks follow the folding. Metaphase - memory is in the mark pattern – chromosome folding will follows the marks science.org/doi/10.1126/sc……
The @Sarkomstiftung had opened the next call for their junior investigator award. For more information please visit sarkome.de/forschung-stud… @sar
great environment - great PI ! Don't miss the chance.
I have 2 #PhD positions opening in my lab @ChariteBerlin - focusing on single cell genomics in #leukemia #immunotherapy #HSCT🖥️🩸⚔️ The positions are funded by @Krebshilfe_Bonn and @EKFStiftung @phd_position #datascience #medtwitter #PhDposition Please apply!😊 Please RT👍