Yaser Hashem
@Hashemyaser4
Group leader (Ph.D.) at the Inserm, in the fields of molecular and structural biology.
It's a great pleasure to share our latest collaborative work detailing the composition and structure of the highly rRNA-fragmented mitoribosome from Apicomplexa, such as Plasmodium falciparum and Toxoplasma gondii, now out in @NatureComms rdcu.be/d3R8C
ROOL monomers entangle with other monomers via strand swapping to form octameric nanocages. nature.com/articles/s4158…
Pre-print out from the @SternbergLab with our contribution on the structural side. Great effort from Matt, Egill Tanner and the rest of the team leaded by awesome Sam! A 1 year effort on my side learning helical reconstruction by cryoEM... 👇
1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: tinyurl.com/mshwjd77
1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: tinyurl.com/mshwjd77
New online! A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients bit.ly/3GjrXRN
New story - the structure of the Vault cap at 2.3 Å! Fantastic work by Huan Li (@huanli00). For more details, read the preprint, or check out my thread at the other place! 😊🟦☁️ biorxiv.org/content/10.110…
🎉 Congrats to ERC grantee Wolfgang Baumeister @MPI_Biochem, awarded the 2025 #ShawPrize in Life Science & Medicine for pioneering work in cryo-ET! Learn more 👉 europa.eu/!JBXDBG #ERCSYG #CryoET #StructuralBiology #shawprize2025 @TU_Muenchen @ShawPrize @maxplanckpress
In our newly published study we show that the proline-rich antimicrobial peptide (PrAMP) Bac5 has a distinct mode of interaction with the ribosome compared to other PrAMPs…academic.oup.com/nar/article/53…
You want to start tomography? Solve structures inside cells? Reach Nyquist😳? We have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software! Hope it will be useful !
I’m happy to share our recent manuscript in which we are structurally and biochemically investigating 3'-5' tRNA splicing ligases, including a #cryoEM structure of the five-subunit D. rerio tRNA ligase complex. jbc.org/article/S0021-…
We are recruiting 🤩🤩🤩!!! If you are looking to establish your lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, apply!!!
🚨Preprint, RT appreciated🙏 Our work ‘Substrate recognition by human separase’ by @JunYu_unige, Sophia Schmidt, @MargheritaBotto @unige_en @UNIGEnews @MoCel_Geneva @DCI_EM and members from the Morgan @UCSF and @FJ_OReilly labs is online. 🔗biorxiv.org/content/10.110…
Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome go.nature.com/3FJLuu0
Out just now at @NatureComms: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells: nature.com/articles/s4146…
3 years after terrible loss (two -80C freezers and back-ups) of almost all of our collection of regular and mutant human, Drosophila, E. Coli and Plasmodium cells, we are still not finished with insurance. I should point out that this was a valuable collection of mutant cell…
Absolutely amazing!! all you need to do know on the structure and the function of the respiratory chain complexes, in situ 🤯🤯🤯 Congrats Florent and co authors for this breakthrough 👏🏻👏🏻👏🏻
The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @ScienceMagazine 🎉 You can find the full story here science.org/doi/10.1126/sc… @luminous_lab did a wonderful job on the cover and animation👩🎨
Molecular machines enable efficient energy production in mitochondria. Using cryo-electron tomography @bengeliscious and @FlorentWaltz have gained insight into the architecture of mitochondria at unprecedented resolution. @ScienceMagazine @snsf_ch ow.ly/irOA50Vm1xK
Our paper “Blocking IF3N delays bacterial translation initiation” is out on #biorxiv Awesome work from @ana_sancas and @Ka_li44 in collaboration with friends from @WilsonLab2 and @akonevega labs! biorxiv.org/content/10.110…
Now published after peer review at @NatureComms…nature.com/articles/s4146…. Great collaboration with @pmilonma and team. Data collected at @CssbHamburg
1/ 🚨 New Paper Alert! Our latest research in bioRxiv uncovers how translation inhibitors kasugamycin, edeine, and GE81112 target different steps in bacterial translation initiation, offering high-resolution insights into their mechanisms. 🧬🔬 #StructuralBiology #CryoEM
The peer-revied version of our paper on the structure of the Nipah virus RNA polymerase in complex with RNA is out in @NatureComms. Congratulations to first-author Fernanda Sala and many thanks to the reviewers for their comments! nature.com/articles/s4146…
Happy to share the latest preprint from our lab led by our very talented postdoc Fernanda Sala! We determined structures of the Nipah Virus RNA polymerase complex in its apo state and with template and product RNA bound during early replication! biorxiv.org/content/10.110…
My first, first author paper is now on bioRxiv! 🤩 Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨ biorxiv.org/content/10.110… Huge thanks to my PI, @kazu_maeshima, for supervision. Amazing collab with @rcollepardo’s group!" (1/n)