Mariusz Czarnocki-Cieciura
@MariuszCzC
structural biologist in the Nowotny lab at IIMCB Warsaw
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…
Szukam zdolnego doktoranta do mojego projektu SONATA (NCN) na Wydziale Biologii UW: „Molekularne mechanizmy stanu spoczynku komórkowego: rola urydylacji i metabolizmu RNA” 🧬 Szczegóły i warunki: biol.uw.edu.pl/wp-content/upl…
That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv! biorxiv.org/content/10.110…
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? biorxiv.org/content/10.110…
I am pleased to announce Reactor—the complex formation calculator for multi-component protein complex formation experiments: reactor-farnunglab.pythonanywhere.com Developed by the Farnung Lab @harvardmed 1/n
Ready to explore the world of phages through transcriptomics and advanced microscopy? Apply now to join our research team! @IIMCB_Poland
Happy to share Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes. In collaboration with León D. Islas and Tamara Rosenbaum | PNAS pnas.org/doi/10.1073/pn…
High-resolution cryo-EM structures of small protein-ligand complexes near the theoretical size limit biorxiv.org/content/10.110… #biorxiv_biophys
🚨 Postdoc Opportunity Alert! I'm currently looking for a postdoc to join our research team! If you're passionate about developmental neuroscience and drug discovery, this could be your next big step. 👉 euraxess.ec.europa.eu/jobs/353745 #ResearchInnovation #Jobs
CryoDRGN-AI ❄️🐉🤖 is now published in @naturemethods!!! So excited to see this out and a huge congrats to @axlevy0 and team! CryoDRGN-AI extends cryoDRGN from requiring input, fixed camera poses, to end-to-end ab initio reconstruction of biomolecules and their conformational…
We present DRGN-AI for fast, ab initio cryo-EM reconstruction! * learns a neural field from unposed images, * designed for single-shot reconstruction of unfiltered datasets, * finds new states missed by prior approaches! Teamwork led by @ZhongingAlong drgnai.cs.princeton.edu 1/
Structural biologists- join us to work on the mechanisms of protein transport to mitochondria! We work in the interdysciplinary group and in collaboration with structural groups. !Structural friends please distribute! 😊
The AMBER call is still open and will close on September 8th. We are seeking a passionate Postdoctoral Researcher to investigate the mechanisms driving protein transport into mitochondria in Prof. Agnieszka Chacińska's group. lnkd.in/etNHhNXf
Please check out the newest preprint from our lab (with my small contribution) :)
I am very excited to share our recent preprint in which we are structurally investigating macromolecular complexes that contain DNA-binding proteins ICP8 of Herpes Simplex Virus 1 and BALF2 of the Epstein-Barr Virus. biorxiv.org/content/early/…
Here it comes! A long-awaited paper led by @MatyldaIzert and @m_gorna is now out. It features multi-mode approach combining different techniques including our Glacios-made 2.45A cryo-EM stucture of GroTAC peptide interacting with GroEL protein (PDB ID: 8S32).
Fantastic work by @MatyldaIzert pioneering Targeted Protein Degradation in Escherichia coli using a PROTAC-like approach!🎉 embopress.org/doi/full/10.10… Could the future of antibiotics be #TPD?💊🧫 Thanks to FIRST TEAM @FNP_org_pl funding
We are looking for a Project Associate-I to work on an exciting DBT-funded project on DNA repair & recombination. If you have hands-on in planta experience in Arabidopsis, protein-DNA/protein-protein interaction studies, we would love to hear from you!
Structural insights into DNA annealing and recombination by herpesviral DNA-binding proteins ICP8 and BALF2 biorxiv.org/content/10.110… #biorxiv_molbio
Rekrutujemy! Doktorat u mnie w labie, w projekcie i pod opieką Olgi Iwańskiej w ramach Sonata NCN
🚀 Super excited to share our new work, led by @SchnapkaV 🚀 bAIes, a Bayesian framework for generating accurate atomic-resolution ensembles of disordered & multi-domain proteins using #AlphaFold info! Now on @biorxivpreprint @ERC_Research biorxiv.org/content/10.110…
New study @biorxivpreprint We revea, how TnsC filaments form and grow in #CRISPR-associated transposons using #FreeEnergy sims & introduce #DeepLearning-based Graph Attention Networks for decoding biomolecular systems! biorxiv.org/content/10.110… #GNN #StructuralBiology
Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ... @theliulab and team show how cross-linking MS can be used to build novel models of unknown complexes, like a giant virus❄️ ❄️biorxiv.org/content/10.110…
Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of norovirus replication (🧵) 🔗biorxiv.org/content/10.110…