Iannacone Lab

1/ 🚨 Hot off the press in @NatImmunol: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. nature.com/articles/s4159… 🧵(1/11) 2/…

Excited to share that I am stepping in as the new Editor-in-Chief of the @EurJImmunol (EJI)! I feel truly honored to take on this role, following the outstanding work of my predecessors, Chiara Romagnani and Jim Di Santo. At EJI, we remain committed to publishing rigorous,…

Research from Drs. @ValentinaVenzin, @CristianBecc, and the @iannaconelab identifies the molecular and cellular mechanisms by which CD4⁺ #Tcells can restore antiviral CD8⁺ T cell function in the #liver. @NatImmunol: go.nature.com/3Ggjajr 🎧: bit.ly/3IzXLT9

📢 @ValentinaVenzin, @CristianBecc, and a team in the @iannaconelab showed that CD4⁺ T cells can license #Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. go.nature.com/3Ggjajr

Thanks Brenda and @DrSifuJG for highlighting our recent @NatImmunol paper (25:40) immunologypodcast.com/ep-109-phagocy…

Happy to share our latest review "Targeting HBV with RNA interference: Paths to cure" | Science Translational Medicine science.org/doi/10.1126/sc… written together with @CristianBecc, Lena Allweiss, Julie Lucifora, John Tavis, @DrAGehring and Maura Dandri

Do not miss it 👇

We are excited to share our new study @Cancer_Cell identifying Zeb2 as a master genetic switch controlling the tumor-associated macrophage (TAM) program. Led by @FadiSheban, @TgSanPhan, @CuriousKX & @FlorianIngelfi1. (1/20) cell.com/cancer-cell/fu…

T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses embopress.org/doi/full/10.10… @iannaconelab @EleonoraSala12

💡Exciting news! Our latest study, in collaboration with Prof. Mirela Kuka’s lab, is out now—uncovering how T cell–derived IFN-γ can suppress T follicular helper (TFH) cells and limit antibody responses. 🚀🧵(1/10) embopress.org/doi/full/10.10… 🔬Approach: We used a subcutaneous LCMV…

Honored to receive the 2024 @AisfFegato -Italian Association for the Study of the Liver- award for the best basic science publication. I humbly retire the prize on behalf of all co-authors from @iannaconelab and our amazing national & international collaborators. Kudos to all!

🚨 New EJI-EFIS Prize for ECRs! 🚨 🏆 €5,000 award for the best research article in EJI by an Early Career Researcher! 🎤 Winner presents at ECI + receives an EFIS–EJI travel grant! 🔗 Apply now: onlinelibrary.wiley.com/page/journal/1… #ECR #Immunology #EJI #EFIS #ScienceFunding

The UNION consortium is excited to announce 17 open #PhD positions! UNION aims to address the challenges of our ageing society. It involves experts from various disciplines (PIs tagged below) and uses cutting-edge technologies. Contact the individual PIs with your EOI

As a proud member of the organizing committee, I am excited to present to you the SMART Symposium in Immunology – Deconstruction and Reconstruction of Lymphocytes for Precision Medicine, organized by Drs. Hai Qi @Qi_Tsinghua, Mark Davis, Carola Vinuesa @carovinuesa, and Laura…

Excited to share our "Year in Review" perspective in @NatRevGastroHep, where @ValeFuma91 and I highlight key advances in understanding #HBV infection from 2024! We focused on three groundbreaking studies that redefine HBV-specific CD8+ T cell dysfunction: 1️⃣ Heim et al.…

💥New Perspective Alert! In this piece, we introduce the concept of "Regionalized Medicine" and explain how it leverages local immune responses within specific tissue niches to enhance therapeutic precision. 🧬A joint effort with @MarcoDegiov89 & @inversodonato in @embojournal.…

Who says scientists are boring? Social evening and music provided by Matteo Iannacone and the Killer Cells (Silver Trumpet Sextet)

💥 New Review Alert in @NatRevImmunol! Thrilled to share our latest publication on CD8+ T cell dysfunction in chronic #HBV infection, written with Robert Thimme and @Anto_Berto. 🧬 doi.org/10.1038/s41577… 2/ 👀 What’s it about? We explore how CD8+ T cells, crucial for…