Francesca Perrone
@Franc_Perrone
Postdoctoral Scientist working on human intestinal organoids and IBD. Interested in molecular medicine and innovative therapeutic approaches
Another medical milestone! The first patient treated with a prime edited therapeutic shows positive clinical outcomes consistent with effective rescue of his chronic granulomatous disease (CGD), a debilitating and life-shortening primary immunodeficiency. At least 19 base editing…
Our single-cell integration study maps the entire GI tract, revealing how epithelial cell metaplasia contributes to inflammation in IBD and colorectal cancer. 🧬🦠 Explore the #GutCellAtlas at 🌐 gutcellatlas.org! congrats to @AmandaOPhD and team! @sangerinstitute
#GUTVideo from the paper by Dennison et al on "Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease" via bit.ly/4gEcx7X Paper: bit.ly/3Th1zLF @Zilbauer_M…
Such an innovative targeted protein degradation technology developed by @guipap_ and Lauren Miller at the @MRC_LMB. Simple and effective, how research should be!
Super excited to share our latest paper on a novel targeted protein degradation technology, now out in @CellCellPress. We introduce RING-Bait technology, an innovative approach to selectively target and degrade intracellular protein aggregates (1/7) cell.com/cell/fulltext/…
Thrilled to see our research published! We identified disease-associated DNA methylation changes and showed that these differences correlate with clinical outcomes. #organoids #patients #crohnsdisease gut.bmj.com/content/early/…
Great work by @thomasdennison, Heuschkel, @Franc_Perrone, @Zilbauer_M, and their co-authors! The paper is available in @Gut_BMJ: gut.bmj.com/content/early/… #organoids #biobank #epigenetics #crohnsdisease #NAMs
Very proud that our work will make a difference in the development of personalised medicine for #Crohn’s Diseasea
Lab-grown 'mini-guts' could help in development of new and more personalized treatments for #Crohn'sDisease @Cambridge_Uni medicalxpress.com/news/2024-06-l…
Excited to share our latest contribution to the #HumanGutCellAtlas project: a comprehensive guide on how to coordinate efforts and integrate datasets to facilitate the development of the Human Gut Cell Atlas. nature.com/articles/s4157…
Check out our last publication on human #gut #organoids!!
Study finds human gut organoids change DNA methylation in culture @rachelomics @Franc_Perrone ow.ly/XKI950LGkH8
The second issue of our paediatric gastroenterology research team's newsletter has published! This month features a piece on how your cells react when you have inflammatory bowel disease (#IBD). Read the full issue here: orlo.uk/ojxMZ #Research
Interested in working with #organoids and understanding the mechanisms involved in the development of #gut #cancer in Cystic Fibrosis patients? Apply to the PhD position in our lab to join an exciting research and lab environment.
A very exciting reading about the implication of organoids in translation medicine. So happy to work with #intestinal #organoids and to contribute in basic research and biomedical advances
Dr. Francesca Perrone (@Franc_Perrone) et al highlight some of the key aspects that need to be considered and provide an outlook for the future development of human #intestinal #organoids. go.nature.com/3paoda8
🛠️ Creating a functional genetic toolbox for human tissue-derived #organoids: Dr. Emma Rawlins at the @wellcometrust report on how new tools will facilitate gene perturbation studies in tissue-derived organoids facilitating human disease modeling. bit.ly/3Brd0VW
Open PhD position in my group at @humantechnopole to study the molecular basis of thyroid function and disease using cryo-EM and biochemistry❄️🔬 👩🔬🧑🔬 Project here👉semm.it/content/struct… Apply here👉semm.it/education/how-… Please share and feel free to email me for more info!
SARS-CoV-2 Spike cleavage is crucial for virus entry and for triggering cell-cell fusion between infected and uninfected cells. We show that furin is not the only protease involved in Spike cleavage at the S1/S2 multibasic site. 1/3 journals.plos.org/plospathogens/…
Check the last finding on the human gut development and its link to Childhood Crohn’s Disease. Congrats to @elmentaite, Alex Ross, Matthias Zilbauer and @teichlab for this fantastic work! sciencedirect.com/science/articl…
Glad to show you my PhD work finally published ! We developed a new functionalised polymer able to target specifically hepatic cancer cells as a promising therapeutic strategy for the Hepatocellular Carcinoma treatment. Click to know more.. sciencedirect.com/science/articl…
Our 5-year work is finally out! We are able to engineer transplantable intestinal grafts using patient-derived #organoids and decellularized scaffolds with the hope to treat children with inesting failure. @paolodecoppi @Laween_Meran nature.com/articles/s4159…