Michele Gabriele 🔬🧬📸
@labronic_mike
from 🇮🇹 | former @AICF_nyc and K99 fellow @MIT | #newlab in SR-TIGET June 2025 | #Chromatin | #Microscopy | #FirstGen
Starting 2025 with a genome architecture paper about absolute quantification of looped states, lead by James Jusuf!
Mostly on BlåSky but excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we perform absolute quantification of looping (e.g. this loop is present 3%). We quantify mESC 36k loops: <loops> are generally rare (2.3%). biorxiv.org/content/10.110…
Our preprint by @DomenicNarducci and the companion preprint by @deWitLab are now out in @MolecularCell ZNF143 is not a general looping factor and was identified as such due to a non-specific antibody. Instead it is TF with the longest residence time measured (to our knowledge)
(1/14) Excited to share our new work on ZNF143/ZFP143 by @DomenicNarducci ZNF143 has been widely reported to be a general loop factor Instead we and @deWitLab in a companion preprint show that ZNF143 is a TF with no loop function: biorxiv.org/content/10.110… biorxiv.org/content/10.110…
At SR-Tiget we are seeking outstanding mid-career scientists in Computational biology, AI, and Molecular immunology who wish to translate their results into therapeutic advances with a focus on genetic diseases! Deadline 1st September 2025! linkedin.com/posts/sr-tiget…
Proud to announce the latest release of 🧬#Oxbow🏹, with new features to make NGS data analysis more powerful, efficient, and "composable". Learn more at: oxbow.readthedocs.io
Have you recently finished your PhD and had excellent productivity? Telethon foundation is starting a postdoctoral program with a competetive 3-years fully funded position! Send CV and PI preference (included me, I am not yet in the website) details here: back.fondazionetelethon.it/uploads/2025/0…
Are you a mid-career group leader in computational bio/AI/molecular immunology who wants to move the lab to Italy? (preferentially from USA?) The SR-TIGET (Milan, Italy) is recruiting someone like you! Here the call: back.fondazionetelethon.it/uploads/2025/0…
3/ We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
This new preprint from my labmates provides a new perspective on chromatin dynamics! Strongly suggested to everyone into chromatin given its broad impact!
1/ Super excited to share my first preprint from @hansen_lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
New exciting discoveries about ADNP and its role in neurodevelopment!
I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in #ASD and beyond. It has been an exciting ride to share with @AVitriolScience, Mariana, and the people of @gtesta72 and @raymondpoot Lab. Full paper here: biorxiv.org/content/10.110… Thread below 🧵
I am happy to share that our preprint about the modeling of #YY1 haploinsufficiency has been published as open access! You can find it here: nature.com/articles/s4138… #organoids #gabrieledevriessyndrome #ipscs #epigenetics @gtesta72 @AVitriolScience @FPereiraMarlene
Proud to share the first neuronal model of the disease we discovered in 2017! Here we describe that #YY1 mutations affect corticogenesis in a cell-type specific fashion, and in #organoids, we observed a phenotype that recapitulates clinical features!
What a beautiful home for our multiplexed organoids! Kudos to all the members of the @gtesta72 lab who contributed to the project. And a big shoutout to Philipp Dexheimer for this absolute piece of art!🎨
Our February issue is live! 🎉 nature.com/nmeth/volumes/… On the cover, a human brain emerges from multiple stem cell lineages, representing a method to link genetic variation to neurodevelopmental trajectories. Paper here: nature.com/articles/s4159… Image by Philipp Dexheimer.
Super excited to share our new study from the @JD_Buenrostro Lab in @Nature! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning. Paper: nature.com/articles/s4158…
I made a B$sky profile, you can find me here: bsky.app/profile/michel…
📢 Paper alert! Our paper on cortical brain organoids multiplexing is out @naturemethods. nature.com/articles/s4159… Together with the Research Briefing nature.com/articles/s4159… /1
1/10🚨 New Findings Alert! 🚨 Discover how genomic heterogeneity and ploidy help predict intrinsic resistance to anti-PD-1 immune checkpoint blockade (ICB) in metastatic melanoma. 🧬science.org/doi/10.1126/sc… 📝 Key takeaways from our latest study: 🧵👇