Victor V. Lobanenkov
@boris_ctcf
Verifiable facts and personal notes related to paralogous CTCF & CTCF Like BORIS factors which share eleven near-identical DNA\RNA\protein-binding Zn fingers
Finally, our "Cover Art" came out online ! In the image, CTCF is shown as Sisyphus, endlessly pushing a nucleosome, the basic unit of chromatin, up a hill academic.oup.com/nar/issue/53/12
👻 Earth will spin faster on July 22 to create 2nd-shortest day in history space.com/astronomy/eart…
The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis Nature Communications doi.org/10.1038/s41467…
Finally, our "Cover Art" came out online ! In the image, CTCF is shown as Sisyphus, endlessly pushing a nucleosome, the basic unit of chromatin, up a hill academic.oup.com/nar/issue/53/12
Night sky for tonight: Visible planets, stars and more in this evening's sky space.com/news/live/nigh…
See this Instagram video by @abc7gmw instagram.com/reel/DMLVM5_x2…
Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* thinking. Students, academics, and anyone else who outsources their writing to LLMs will find their screens full of words and their minds emptied of thought.
Here is a wjla.com article that you might also like: wjla.com/good-morning-w…
DeepMind’s new AlphaGenome AI takes long (1MB) stretches of DNA to predict various properties such as the expression levels of the genes they contain, how those levels could be affected by mutations, and even 3D DNA loops of enhancer-promoter links, etc. deepmind.google/discover/blog/…
CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation M. Tajmul, D. N. Bhatt, L. Ruje, E. Price, Y. Ji, D. Loukinov, V. B. Teif, V. V. Lobanenkov, E. M. Pugacheva revised May 23, 2025 biorxiv.org/content/10.110…
New moon of June 2025 sees Mercury climb to its highest point in the sky space.com/stargazing/new…
CTCF maintains pericentromere function and mitotic fidelity Preprint posted on bioRxiv (June 3, 2025) by Erin Walsh and Andrew Daniel Stephens doi.org/10.1101/2025.0…
Deciphering the role of RNA in regulating DNA binding CTCF affinity in chromatin Genome Biology paper (May 12, 2025) published by Judith Hyle et al. doi.org/10.1186/s13059…
CTCF-binding silencer in the WT1 anti-sense regulatory region (WT1 ARR) regulates imprinting of AWT1 and WT1-AS genes, and exhibits sequential epigenetic defects during Wilms’ tumor genesis Hum Mol Genet 2007 paper by Anne Hancock and coauthors from V. Lobanenkov & K. Malik labs
Post-fertilization initiation of anti-sense transcript in ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2 in rabbits and macaques eLIFE publication (June 2, 2025) by Hisato Kobayashi, corresponding author and 22 coauthors doi.org/10.7554/eLife.…
Post-fertilization initiation of anti-sense transcript in ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2 in rabbits and macaques eLIFE publication (June 2, 2025) by Hisato Kobayashi, corresponding author and 22 coauthors doi.org/10.7554/eLife.…
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma PNAS U S A. 2002 May 14; 99(10): 6806-11 pnas.org/doi/10.1073/pn…
Familial cases of point mutations in the XIST promoter which revealed strict correlation between CTCF binding and preemptive choices of X chromosome inactivation have already provided near direct evidence for the crucial CTCF role in Human X-inactivation pubmed.ncbi.nlm.nih.gov/15731119/
BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites Genome Biol. 2024 Jan 31; 25(1): 40. pubmed.ncbi.nlm.nih.gov/38297316/ genomebiology.biomedcentral.com/articles/10.11…
