Andrew Octavian Sasmita

Are you using 5xFAD mice to study Alzheimer’s disease? Our work @NeuroCellPress may be relevant to you 🐁 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. (1/11) cell.com/neuron/fulltex…

Spatial proteomics of Alzheimer’s disease-specific human microglial states nature.com/articles/s4159…

Astrocytes (🔵) and microglia (🟡) in the hippocampus of a mouse brain for #FluorescenceFriday

"Brain metabolism is a tissue-level phenomenon in which glial cells are not mere assistants but full partners". A short and sweet editorial led by @bolanosjuanp that challenges the neuron-centered view of brain metabolism. onlinelibrary.wiley.com/doi/10.1111/jn…

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease nature.com/articles/s4159…

Mitochondrial origins of the pressure to sleep | Nature nature.com/articles/s4158…

APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases @NatureMedicine nature.com/articles/s4159…

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy. #TIC2025 #microbiota #exercise #immunotherapy cell.com/cell/abstract/…

Microbiota-driven antitumour immunity mediated by dendritic cell migration nature.com/articles/s4158…

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4 dlvr.it/TLsnf0

Behavioral assessment and gene expression changes in a mouse model with dysfunctional STAT1 signaling biosignaling.biomedcentral.com/articles/10.11…

Microglia replacement halts the progression of microgliopathy in mice and humans | @ScienceMagazine science.org/doi/10.1126/sc…

Gonzalez-Ortiz et al. report plasma p-tau217 measurement in newborns; levels are significantly higher in healthy newborns than in AD patients. Levels of serum p-tau217 in premature newborns remain increased up to 18 weeks post birth (buff.ly/7aGVNYq) @Rantes

Rethinking TREM2 as a target for Alzheimer’s disease after the INVOKE-2 trial failure | Nature Medicine nature.com/articles/s4159…

Differences of the 6N and 6J Substrains of C57BL/6 Mice in the Development of Experimental Autoimmune Encephalomyelitis onlinelibrary.wiley.com/doi/10.1002/mc…

#GLIA2025 is right around the corner! Catch the poster presentations from @KlausNave’s group and talk all things glia in health and in Alzheimer’s disease ✌🏼 @gliameeting

Amyloid-beta accumulation in centenarians is associated with reduced cognitive performance and is not a benign aspect of aging. ja.ma/4lskuhU

What is the role of myelin in Alzheimer's disease? Excited to share our new Perspective in @NatureCellBio, where we review the role of oligos and myelination in AD, with Anna Bright, @JoelWBlanchard1 and Li-Huei Tsai. nature.com/articles/s4155…

In this piece of brain tissue the size of sand grain are 200,000 neurons and nearly 2.5 miles of axons. While it may seem small in size, it was previously thought impossible to map. The road to this beautiful image is both a scientific and human triumph: alleninstitute.org/news/scientist…

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity nature.com/articles/s4159…

Hello Everyone! New review alert - a new hypothesis disentangling Alzheimer's & Parkinson's! Lots of co-occurrence in these diseases, including Dementia with Lewy Bodies. It reconciles this common overlap by connecting disease pathologies & senescence: dx.doi.org/10.1002/alz.70…