The Dobreva Lab
@DobrevaLab
We study the interplay between genetics and epigenetics in shaping cell identity, plasticity, and resilience during development and in disease.
Mapping the Future of Organoids 🧠🫁 👉 Read the original publication in Nature Genetics: t1p.de/avhdz What if we could model the complexity of human organs in the lab — and make it reproducible? Scientists at #HelmholtzMunich, together with partners at Roche’s…
Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s4158… Lead by @_xuquan @HalleLennard Collaboration with @fabian_theis @TreutleinLab @IHB_Research
Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk hubs.li/Q037Z6lP0 @UTSWMolBiol @deirdre_logsdon @carlosapinzona @UTSWGreenCenter @YYReprod @leo_jwu Open stem cell research from @CellStemCell
Online Now! Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages dlvr.it/TLLCMC #stemcells
Now online! Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue dlvr.it/TLKJq4
Nature research paper: Metabolic adaptations direct cell fate during tissue regeneration go.nature.com/3FMlpe4
Absolutely crazy month for progress in the world of genome instability & DNA repair, especially as pertaining to aging. A few of the most exciting papers, a 🧵:
The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:
Epigenetics Update - Clonal tracing with somatic epimutations reveals dynamics of blood ageing go.nature.com/43oRfp3 Alejo Rodriguez-Fraticelli/Lars Velten in Nature #Epigenetics #Epimutations #Aging --- Gain deeper insights into gene regulation with epigenometech.com
Nature research paper: Molecular basis of positional memory in limb regeneration go.nature.com/43ay9nM
The @DobrevaLab show that an RNF20-HIF1α axis links the DNA damage response and metabolic reprogramming in #LungCancer. 🫁 📖 More in @NatureComms: go.nature.com/3Fn4kqX
We are excited to share our latest work uncovering how the epigenetic modifier RNF20 links genome stability and metabolic rewiring in lung cancer: @NatureComms rdcu.be/en5Ps
In a new @SciSignal Review, scientists examine an emerging body of research implicating #SleepLoss as a metabolic disorder and discuss its impact on the metabolism of neurons and parallels to neurodegenerative disorders. scim.ag/42opuwh
RESEARCH | @NicolaisenSand, B Kiens et al. (@UCPH_Research) Dietary protein restriction in healthy, lean men elicits increased energy intake to maintain body weight, driven in part by FGF21-mediated alterations to adipose tissue mitochondria. nature.com/articles/s4225…
Study finds that female body takes longer time to recover from pregnancy and childbirth. Honestly, how is this even surprising? Also, the toll of sleep deprivation while caring for the newborn should not be overlooked. Any recovery stalls without sleep. nature.com/articles/d4158…
Online Now! Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids dlvr.it/TJZf3R #stemcells
Check out this interesting Bioengineering conference organized by @NatureConf @natrevbioeng @NatureComms @NatureMaterials @natBME and @NatureCVR and register!
Join us for the Nature Conference: Engineered Models of Human Disease in Belgrade, Serbia, on October 28–29, 2025! Explore the preliminary program and register here: natureconferences.streamgo.live/models-human-d… We look forward to seeing you there!
Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon hubs.li/Q037Z0gv0 Open stem cell research from @CellStemCell
❤️Our March issue is out❤️Featuring the cardiovascular polypill’s path to the WHO’s Essential Medicines list, tricaprin’s applications in cardiomyovasculopathy, NAD+ deficiency in aortic aneurysm, HF targets identified via multi-omics approaches, and more! nature.com/natcardiovascr…
Research| Li et al. show that maternal exposure to a Western-type diet can accelerate atherosclerosis in adult offspring, revealing how AP-1-mediated chromatin dynamics in fetal endothelial cells induce inflammatory memory through 27-hydroxycholesterol. rdcu.be/edUAd
Heart rate matters. Great collaboration with Mike Bristow and many others. Clinical trial, endomyocardial biopsies, new molecular mechanisms of reverse remodeling in the human heart. ahajournals.org/doi/epub/10.11…