Daniel Scott

Our recent publication in Cell Research visualizes continuous motion of nucleosomal DNA by human chromatin remodeler SNF2H. nature.com/articles/s4142…

Thrilled to support #cryoEM research at @StJudeStructBio @StJudeResearch, I teamed up with @Daniel_C_Scott and #SchulmanLab @MPI_Biochem in this beautiful work to uncover the structural basis of C degron selectivity in KLHDCX family E3 ubiquitin ligases 👉 rdcu.be/d0q6Y

Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases, now out @SpringerNature @NatureComms Awesome collaboration with @sagarchittori . @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/d0h2G

Authors @Daniel_C_Scott @Richard_E_Lee @StJudeResearch @StJudeStructBio @MPI_Biochem demonstrate that heterobifunctional degraders induce cooperative ternary complexes with KLHDC2 and BRD3 #ubiquitin #SchulmanLab #E3 ligase #TPD #PROTAC nature.com/articles/s4146…

Our study on the principles of paralog-specific degradation engaging the C-degron E3 KLHDC2 is now out in Nature Communications. nature.com/articles/s4146…

Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms Awesome collaboration with @Richard_E_Lee and Taosheng Chen labs. @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/dWKpF

Charged Molecular Glue Discovery Enabled by Targeted Degron Display biorxiv.org/content/10.110…

Now out in @MolecularCell! High-resolution structure showing direct ubiquitylation of a #TPD substrate! And much more, check out 👉shorturl.at/jrsBG #cryoEM @MPI_Biochem @UNLV_CoS @StJudeResearch @DanielS20127197 @rajanprabu (1/2)

How does multisite #phosphorylation of an #E2 enzyme dictate its pairing with a multisubunit #E3 #ubiquitin ligase to regulate metabolism? Check out our story available now in @MolecularCell! ➡️ cell.com/molecular-cell… @dawafutisherpa Schulman lab @MPI_Biochem

Researchers from Brenda Schulman's lab found an exciting mechanism, the 'rock-and-roll-mechanism', which recycles and re-uses protein modules! ➡️ biochem.mpg.de/rock-n-roll-me… ➡️ cell.com/cell/fulltext/…

In the latest issue! Systemwide disassembly and assembly of SCF ubiquitin ligase complexes dlvr.it/SnCsPj

Excited to share that our work on cullin-RING E3 ligase biogenesis is now officially out in @CellCellPress! A big thank you to @KheewoongBaek and @DanielS20127197 for letting me be a part of this journey. @MPI_Biochem @labs_mann @StJudeResearch tinyurl.com/bdfftx5k

Work from Schulman lab @MPI_Biochem and @StJudeResearch out @CellCellPress shows how CAND1 promotes exchange of F-box proteins in idle SCFs to recycle CUL1 and reveals a new paradigm for remodeling the cellular repertoire of multicomponent complexes. #OA tinyurl.com/bdnz25d6

CAND1 mediates disassembly and assembly of Cullin-RING E3 ubiquitin ligase complexes by rock-n-roll structural mechanism. @KheewoongBaek @DanielS20127197 @LukasHenneberg @labs_mann @stjuderesearch

Now Online C-degron mimicry confers E3 ligase selectivity dlvr.it/SkqCmx

Good things do come in pairs! The new issue of @MolecularCell features two papers from our Department cell.com/molecular-cell…

From the Schulman lab, also @MPI_Biochem: Scott @DanielS20127197 et al. integrate structural and biochemistry to unveil how an E3 #ubiquitin ligase complex discriminates bona fide substrates from proteins with degron-like motifs. Featured Article cell.com/molecular-cell…

Important paper from Danny Scott @StJudeResearch and Brenda Schulman @MPI_Biochem in @MolecularCell showing negative autoregulation of a C-degron E3 ligase. Big ramifications for TPD: compounds need to compete with such cellular control!!! cell.com/molecular-cell…

"This mechanism protects a protein called NEDD8 from degradation," Schulman says. "NEDD8 is a master regulator responsible for many biological regulations that allow many therapies—including targeted protein degradation ones—to work." @MPI_Biochem

Out @MolecularCell from Schulman group @StJudeResearch & @MPI_Biochem: E3 Ub ligase CRL2-KHLDC2 uses a kinetic mechanism and auto-inhibitory self-assembly to avoid targeting non-substrate proteins with degron-like sequence. authors.elsevier.com/a/1gbyX3vVUPNx…