HalicLab

Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H nature.com/articles/s4142… @StJudeStructBio @StJudeResearch

Scientists used cryo-EM to capture 13 distinct structures of the chromatin remodeler SNF2H in action. This research provides a complete view of nucleosome sliding, a key process in gene regulation. ow.ly/mhv150VtUoH

Our recent publication in Cell Research visualizes continuous motion of nucleosomal DNA by human chromatin remodeler SNF2H. nature.com/articles/s4142…

Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: cell.com/cell/fulltext/… Explore this amazing resource here: yslproteomics.shinyapps.io/tissuePPT

In our latest work we visualize continuous motion of nucleosomal DNA by human chromatin remodeler SNF2H. biorxiv.org/content/10.110…

Thrilled to share our first lamellae made here at St. Jude! Great work by Martin, Silvija and Robert!

Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases, now out @SpringerNature @NatureComms Awesome collaboration with @sagarchittori . @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/d0h2G

A preprint from the lab led by graduate student Dana R Kennedy. doi.org/10.1101/2024.1… Over 20 years ago, the Eissenberg lab showed that phosphorylation of HP1 is important for its silencing function. Why? Key observations from our study in fission yeast:

We have exciting news to share! Abhay Kotecha (@abhaykot) is joining us as Senior Director of Technologies for Cryo-EM and Cryo-ET. We're thrilled to have him continue his great work in #CryoET, building on his innovation at @thermosciEMSpec. Welcome to @stjuderesearch, Abhay!

Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms Awesome collaboration with @Richard_E_Lee and Taosheng Chen labs. @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/dWKpF

Still hot off the press — @kellogg_liz and colleagues present the first structure of a Fanzor2! Fanzors are eukaryotic RNA-guided DNA endonucleases. With the available Fanzor1 structures, the new work offers a comprehensive view of the family's evolution nature.com/articles/s4159…

St. Jude names M. Madan Babu, PhD, as Chief Data Scientist. He’ll lead the new Office of Data Science, advancing biomedical research with 115 new roles. His work will help integrate vast datasets and improve patient care. #DataScience #BiomedicalResearch ow.ly/gQbN50TAASu

Happy to share our latest work from the @kellogg_liz lab, in collaboration with the Protein Technologies Center at St. Jude, where we describe the structure of Fanzor2. Special thanks to my co-authors, Zuhaib Qayyum and Ajay Tanwar. nature.com/articles/s4159…

Our latest paper is out! In collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/…

We are thrilled to welcome the incomparable Yiorgo Skiniotis and his lab! Yiorgo will also lead the new Center of Excellence for Structural Cell Biology, to advance cryoET and other cutting-edge approaches @StJudeResearch, paving the way for new, exciting biological insights!

Building on the work of Richard and Chris, here is our latest work showcasing the potential of the 100 keV #Tundra microscope with the Ceta F and Falcon C. We achieved high-resolution structures for a variety of protein complexes🧵.🔬#100keV #CryoEM. Movie by @lingboyu

Our work on human urate transporter is out @cell_res. @YaxinDai single-handedly drove this project, which revealed the transport and drug mechanism of URAT1. We are grateful for the tremendous support from @StJudeStructBio nature.com/articles/s4142…

🚨 New Research Alert! 🚨 Excited to share our latest paper on PHF6's role in linking H3K14 acetylation, #SWISNF, and #RNApolymerase complexes. Now live in @NatureComms! 🎉 Big congrats to the first author, @priya1012007, and all co-authors! 👏 nature.com/articles/s4146…

It is great fun to collaborate with @mjafreeman, the leading expert in the field. @lu_fangfang and @HongtuZhao worked together to reveal the structures of the ADAM17 sheddase complex and showed how iRhom2 restrains ADAM17 protease activity. sciencedirect.com/science/articl…

Just in time for #HumpDay: Our study Targeting DCAF5 suppresses #SMARCB1-mutant #cancer via stabilizing SWI/SNF is online now in @Nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and @HongYue88665668 and all co-authors on this story! 1/ nature.com/articles/s4158…