Sagar Chittori
@SagarChittori
Structural Biologist. CryoEM Scientist at St. Jude Children's Research Hospital. Editor at FrontMolBioSci, FrontYoungMinds, BMCMolCellBiol.
Kudos, Prem!
😃Finally, the book is out, and we have contributed a chapter. Great job by one of my brilliant students, Ankita👏. Thanks to Dr. Appasani for giving us the opportunity. @unescorcb routledge.com/.../App.../p/b…...
@Daniel_C_Scott @sagarchittori and colleagues @StJudeResearch @StJudeStructBio @MPI_Biochem reveals substrate selectivity by E3s with similar structures #ubiquitin #SchulmanLab #E3ligase nature.com/articles/s4146…
Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases, now out @SpringerNature @NatureComms Awesome collaboration with @sagarchittori . @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/d0h2G
Thrilled to support #cryoEM research at @StJudeStructBio @StJudeResearch, I teamed up with @Daniel_C_Scott and #SchulmanLab @MPI_Biochem in this beautiful work to uncover the structural basis of C degron selectivity in KLHDCX family E3 ubiquitin ligases 👉 rdcu.be/d0q6Y
Had two fantastic days at the @StJudeStructBio departmental symposium! Kudos to all the speakers for their incredible presentations and to the organizers for making it a huge success and fun!!
All ready for our upcoming symposium here at St. Jude. We have a stellar lineup of speakers and over 250 registered attendees! Looking forward to two days of exciting science!
Had a great time at the #MicroED workshop at #UCLA organized by @gonenlab and @BrentNannenga. Special kudos to all speakers and instructors including @ThermoFisher team for complementing excellent lectures with practical sessions covering sample prep to structure determination.
#StJudeCryoEM update: single particle reconstruction of apoferritin from ~4700 micrographs collected on Krios G3i with K3 detector and energy filter setup @StJudeStructBio, data processed using #RELION 4.0
Interested in learning about #antibioticresistance bacteria but don't know where to start? Here is a great article by @FrontYoungMinds on superbacteria in seafood. kids.frontiersin.org/articles/10.33…
Peer reviewing is so much fun with kids. A great initiative by @FrontYoungMinds @FrontiersIn for introducing kids to the scientific world. kids.frontiersin.org/articles/10.33…
One-shot from biochem to structure, for my first ever apoferritin prep. This mini in-house project was possible, thanks to my wonderful colleagues in the @StJudeStructBio #CryoEM Center and a great collaboration formed with the Protein Technologies Center.
Published in @jbiolchem: we report several cryo-EM structures of human p97, providing a detailed understanding of the allosteric changes induced by disease-causing mutations and binding of an active site inhibitor CB-5083. jbc.org/article/S0021-…
#innateimmunity This @FrontYoungMinds article explains innate immunity, our body's first line of defense against pathogens like viruses and bacteria. Enjoyed teaming up with Science mentors and Young reviewers for my first editorial contribution. kids.frontiersin.org/articles/10.33…
Frontiers for Young Minds, a fantastic platform for kids, is bringing out an inspiring collection of articles written by Nobel laureates and reviewed by kids. I could say, a must-read for all ages!!! kids.frontiersin.org/collections/21…
Congratulations Bharath. A timely article on the importance of kinetic studies in drug discovery.
An article that demonstrates the repurposing of FLIPR tetra for high-throughput kinetic studies journals.sagepub.com/doi/10.1177/24…
Self-assembled monolayers improve protein distribution on holey carbon cryo-EM supports disq.us/t/1wtrvqd
Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains doi.org/10.7554/eLife.…
Check out our latest manuscript on chromatin remodeling published in Nucleic Acids Research @NAR_Open #CryoEM #Chromatin #Nucleosome #ISWI #Cancer academic.oup.com/nar/advance-ar…
Glad to see the citation of our work (nature.com/articles/natur…) in this month's entry of PDB Molecule of the Month:
AMPA Receptor: Receptors for the neurotransmitter glutamate in our brain come in several shapes and sizes. More at Molecule of the Month: pdb101.rcsb.org/motm/235