Jakub Chrustowicz

Thrilled to share our latest preprint describing discovery of the charged, metabolically activated molecular glue degrader engaging the basic pocket of the structural CRBN homolog, YPEL5 - a subunit of the giant GID/CTLH E3 ligase!!! biorxiv.org/content/10.110…

Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms Awesome collaboration with @Richard_E_Lee and Taosheng Chen labs. @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/dWKpF

Can we turn the activity of oncogenic kinases against cancer itself? In my postdoc work @Stanford, new in @sciencemagazine, we show exactly that. science.org/doi/10.1126/sc… #ScienceResearch #InducedProximity @Stanford_ChEMH @StanfordCancer @snsf_ch @StanfordMed

Cool new preprint on prodrugged molecular glues by ⁦@Stanford_ChEMH⁩ institute scholar Nathanael Gray and coworkers ⁦@StanfordCancer⁩ ⁦@StanfordMed⁩ Charged Molecular Glue Discovery Enabled by Targeted Degron Display | bioRxiv biorxiv.org/content/10.110…

🔬 Neat discovery in protein degradation. Gray, Schulman, et al labs unveil ZZ1, a prodrug for charged molecular glues that target disease-causing proteins via the GID/CTLH ubiquitin ligase complex. biorxiv.org/content/10.110…

⭐️ Editor's Choice article: Mutations in WDR26 associated with #SkrabanDeardorffsyndrome (#SKDEAS) impair CTLH E3 complex assembly ➡️ doi.org/10.1002/1873-3… @pjmurray_lab @MPI_Biochem

Check out our story revealing exciting regulation of the NAD+ biosynthetic enzyme NMNAT1 by the supramolecular CTLH E3 ligase assembly out in @MolecularCell! ➡️cell.com/molecular-cell… Karthik Gottemukkala, @dawafutisherpa, @ArnoAlpi Schulman lab @MPI_Biochem

Wow! CUL9 is a GIANT E3 ubiquitin ligase!  See unique cullin-RING-RBR all-in-one. +/- NEDD8. Now online in Nature Structural & Molecular Biology by Schulman Department ❕nature.com/articles/s4159… #ubiquitin #E3ligase #cryoEM @DHornGhetko @LinusHopf @labs_mann @NatureSMB

🚨Excited to share that our manuscript is now published in @NatureSMB. Using #cryoEM 🔬we obtained multiple snapshots 📷 of the #chaperone-mediated multistep assembly pathway of the human 20S #proteasome. @MPI_Biochem @HarvardCellBio @ASAP_Research nature.com/articles/s4159…

Here is the link to our SKDEAS paper: 10.1002/1873-3468.14866. And I love this figure. Maybe useful for the @Skdeas.org effort.

Back after an Easter X-break with a new paper from PhD student Annette Gross, @ArnoAlpi and the Schulman team explaining how the huge spectrum of WDR26 mutations is involved in #Skraban-Deardorff intellectual disability syndrome

Now out in @MolecularCell! High-resolution structure showing direct ubiquitylation of a #TPD substrate! And much more, check out 👉shorturl.at/jrsBG #cryoEM @MPI_Biochem @UNLV_CoS @StJudeResearch @DanielS20127197 @rajanprabu (1/2)

How does multisite #phosphorylation configure the catalytic E2-E3 assembly for metabolic enzyme targeting? Check out our story available now in its final version in @MolecularCell! ❕cell.com/molecular-cell… @chrustowicz_j @dawafutisherpa #ubiquitin

How does multisite #phosphorylation of an #E2 enzyme dictate its pairing with a multisubunit #E3 #ubiquitin ligase to regulate metabolism? Check out our story available now in @MolecularCell! ➡️ cell.com/molecular-cell… @dawafutisherpa Schulman lab @MPI_Biochem

Which cullin-RING E3 #ubiquitin ligase directs your favorite pathway or your #DegraderDrug? Our conformation specific antibody and probing of active #CRL E3 complexes is in @nchembio! ❕mpg.pulse.ly/3m3asipuew ❕nature.pulse.ly/l6c644umev @labs_mann @pjmurray_lab @LukasHenneberg

In preparation for the Louis-Jeantet Prize ceremony, we accompanied the @LouisJeantetFDN video team to shoot parts of the video about our director Brenda Schulman, @iDikic2 and their amazing research in the #ubiquitin field. Watch the full video here: ➡️ youtube.com/watch?v=UDBQOR…

Systemwide multiprotein complex formation visualized! CAND1 recycles Cullin-RING complexes to produce E3 #ubiquitin ligases. Averts cellular supply chain problems, prevents buildup of unneeded molecular machines & rapidly establishes degradation pathways ➡️tinyurl.com/bdnz25d6

📣 Amazing News! We're happy to announce, that Brenda Schulman receives an ERC Advanced Grant for her project UPSmeetMet! Congratulations to all ERC-Awardees! 🎉 ➡️ more: biochem.mpg.de/brenda-schulma… @ERC_Research #ERCAdG #Ubiquitin

Now Online C-degron mimicry confers E3 ligase selectivity dlvr.it/SkqCmx