Green Research Group
@GreenGroupMIB
Student-run account for the Green group (MIB). Enzyme design. Directed evolution. Genetic code expansion. Industrial biocatalysis.
Congratulations to our group members Anna and Emily for winning presentation and poster prizes respectively, in the biological section of the 2025 UoM Chemistry PGR Conference! 🎉🎉🎉


Very happy to announce that 'Efficient and selective energy transfer photoenzymes powered by visible light' is out today in Nature Chemistry! Congratulations to Rebecca, Ross and everyone else involved in this project! 🎉🎉🎉 nature.com/articles/s4155…
Delighted to announce that 'Engineered enzymes for enantioselective nucleophilic aromatic substitutions' is out now in Nature! Congratulations to Tom, George and everyone else involved in this project! 🎉🎉🎉 nature.com/articles/s4158…
Exciting PhD opportunity in microfluidics and therapeutic peptide discovery! Join a collaborative team at the University of Manchester for a fully funded PhD in the Obexer, Markin, Hurd and Barran groups. tinyurl.com/2z29ybjw
Applications are now being accepted for Senior Technician (Biomolecular Engineering) and Senior Technician (Bioautomation and high-throughput analytics) roles within the MIB. Please see links below for details and for how to apply. jobs.manchester.ac.uk/Job/JobDetail?… jobs.manchester.ac.uk/Job/JobDetail?…
Very happy to announce that 'Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site' is out now in JACS! A really exciting collaboration with @UWproteindesign 🎉🎉🎉 pubs.acs.org/doi/10.1021/ja…
Very happy to the share the news that 'An enzyme cascade enables production of therapeutic oligonucleotides in a single operation' is out now in Science! Great work by @LovelockLab 🎉🎉🎉 science.org/doi/10.1126/sc…
Science meets Christmas! Thanks Emily for the delicious gingerbread lab bench🎄

Very excited to announce our latest paper, 'A Designed Photoenzyme for Enantioselective [2+2]-Cycloadditions', is out now in Nature as an AAP! Congratulations Jonathan, Rebecca and everyone else involved 🎉🎉🎉 nature.com/articles/s4158…
The Lovelock group are hiring 3 Postdoctoral Researchers Associates in #biocatalysis and #proteinengineering to join their team at the Manchester Institute of Biotechnology jobs.manchester.ac.uk/displayjob.asp…
Very excited to announce that 'Directed evolution of an efficient and thermostable PET depolymerase' is out now in Nature Catalysis! Congratulations Izzy, Ross and everyone else involved 🎉🎉🎉 nature.com/articles/s4192…
Bank holiday reading anyone? Review 'The road to fully programmable protein catalysis' from Baker/Hilvert/Green nature.com/articles/s4158…
Very happy to be sharing this work fresh on the @ChemRxiv this morning from the Green group! ''A Designed Photoenzyme Promotes Enantioselective [2+2]-Cycloadditions via Triplet Energy Transfer'' chemrxiv.org/engage/chemrxi…
Big smiles for Rebecca's graduation day, congratulations! 🍾🍾🍾

Congratulations to the Turner group on their latest paper, 'Multifunctional biocatalyst for conjugate reduction and reductive amination'! Out now in @Nature, nature.com/articles/s4158…
We are excited to share that our work on a multifunctional enzyme that catalyses conjugate reduction and reductive amination is out now in @nature! This was a collaboration with the Grogan group @YSBL, @Prozomix and @pfizer nature.com/articles/s4158…
Very happy to announce that 'Directed Evolution of an Efficient and Thermostable PET Depolymerase' is now available to read on the ChemRxiv archive, congratulations to Izzy, Ross and everyone else involved! 🎉 chemrxiv.org/engage/chemrxi…
Massive congratulations to Rebecca, Amy and everyone else involved in 'Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction' 🎉🎉🎉 Out now in Nature Chemistry rdcu.be/cDlYx
We're happy to present our work on the biocatalytic manufacture of Molnupiravir with @GreenGroupMIB and @Prozomix: Gates Foundation funding for University to develop low cost manufacturing route to the promising COVID-19 therapy Molnupiravir manchester.ac.uk/discover/news/…
Massive congratulations to Rebecca and Ashleigh for passing their PhD vivas this week!!! Can't wait to see where your futures take you 🎉

We are happy to announce that additional experimental data has been added to Ashleigh's paper on the ChemRxiv archive. In particular, a more highly evolved cytidine amino transferase has been developed and the sequence is published here. chemrxiv.org/engage/chemrxi…