Alessandra Boletta
@Boletta_Lab
Cell Biologist with interest in renal disorders #PKD #cilia #cancermetabolism Ts&RTs=my view
🎉Beyond happy to receive an #ERCAdG! @ERC_Research QtCilia studies a novel nutrient sensing role of #cilia (@NatMetab rdcu.be/dDTn3).We will study how #cilia sense glutamine(Q) and talk to #mitochondria to regulate #metabolism. In health and disease #ciliopathies #PKD
Beautiful beautiful interview Fouad! Congrats!
🚨 New podcast episode! I sat down with Dr. Koren—clinical trial pioneer and our neighbor here in Jacksonville—to discuss the exciting future of PKD research. If you or a loved one is exploring clinical trial options, don’t miss this conversation. 🎧👇 medevidence.com/whats-on-the-h…
1/ 🧬 Exciting news! Our group just published our study on using serum proteomics to predict disease progression in #ADPKD (Autosomal Dominant Polycystic Kidney Disease) 🔬 — enhancing risk stratification beyond currently available models 🎯 rdcu.be/exbNq
Proudly presenting Simon’s paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @NatMetabolism nature.com/articles/s4225… @helsinkiuni @HiLIFE_helsinki @SuomenAkatemia @MetaStem_Center
📢 Just out in @KidneyNews: Our latest article breaks down the 2025 KDIGO guidelines on genetic testing in #ADPKD — who to test, why it matters, and how genotypes guide prognosis and management. 🔬🧬 Read it here: kidneynews.org/view/journals/… @ASNKidney @asnpublications…
Kidney News July 2025 @asnpublications Clinical Practice Guidelines for Genetic Testing in ADPKD Neera K. Dahl @pranavgarimella and Fouad T. Chebib kidneynews.org/view/journals/…
This poster is a must have for labs working on #MCS! A guide through the work of so many outstanding labs (apologies if we did not cite your work). Hang it in your office or lab, it will please your eyes and inspire your mind! Kudos to the driving force Antigoni Diokmetzidou! -LS
In their Cell Science at a Glance article, Antigoni Diokmetzidou & Luca Scorrano @LabScorrano summarise the mitochondrial contacts characterised in mammals, the mechanisms underlying their formation, and their principal functions. journals.biologists.com/jcs/article/13… #JCSMitoSI #OpenAccess
Review Article by @Boletta_Lab and Michael J. Caplan (@Yale). Physiologic mechanisms underlying polycystic #kidney disease ow.ly/ulil50Wj8pi #PolycysticKidneyDisease @SanRaffaeleMI
Happy to be the next @CRGenomica director. The CRG always stood out to me for its excellence in decoding life’s principles & its collaborative, open and innovative way of doing science. Thrilled to follow L Serrano footsteps & join its amazing community! crg.eu/en/news/monica…
🥳TheRaCil Publication Alert🚨 Visit theracil.eu/news-and-publi… for the latest findings on #ARPKD by our teams: predictive risk score at the age of 2 months, urinary peptide signatures and perspectives on polycystic kidney diseases in children. #cilia #kidney #kids
My students @AMytlis, @Karine_Le_V, and myself were invited to speak at the @SingerPolignac #Fertilty meeting, Paris. We could not join in person at the current circumstances. This is how I ended my talk: 🔊 @HebrewU @HebrewU_heb @HebrewU_Europe @IsraelAcademy @youngAcademyIL
Favorite study! Germline-somatic tandems dictate cancer subtypes, provide clinical insights, and fuel molecularly informed studies. Kudos: Blerta Stringa, @Paola_Gasperini, Alessandro Alaimo, and @LunardiLabCIBIO (co-last a!) @NimaSharifiMD doi.org/10.1158/2159-8… @UniTrento
💛 A small gesture can change the future for those living with PKD. Polycystic kidney disease continues to affect millions of lives — but with your support, we can take meaningful steps toward hope. Support us today: pkdinternational.org/donate #PKDInternational #ADPKD #ARPKD
We have an open #ERC funded PhD position to work on #cilia #mitochondria #PKD and #matabolism Deadline July 7th. Look forward to welcoming a talented PhD student to our lab in beautiful Milan 👇
New paper on mitochondrial distribution across the human body If you have more mitochondria than the average person in your heart, does that mean you also have more than average in your brain, muscles, kidneys, etc? We investigated inter-organ correlations in mitochondria 🧵
Check out our fresh review on converging mechanisms controlling #cilia dynamics during #cellcycle and #signaling. With @cajaneklab we explored the dual roles of cilia factors and cilium turnover during specific cell fates and cancer. Many more here rdcu.be/epVDc Enjoy🙂
Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail go.nature.com/4dNf8eu
Exciting to see so much traction for genetics in ERA conference Vienna 2025 @MuellerRom @ecorneclegall amazing program president @torra_roser
Thrilled to share our new work in @NatureComms! We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics Here’s a quick breakdown 🔗 nature.com/articles/s4146…
Silencing mitochondrial gene expression in living cells | Science science.org/doi/10.1126/sc…. Wonderful that our paper is out now in Science. A big thanks to LD Cruz-Zaragoza and the team, @warscheidlab & @JakobsLab .
👏👏 Dutcher elected to National Academy of Sciences source.washu.edu/2025/05/dutche…