Joep Beumer
@BeumerJoep
Roche Institute for Human Biology. @IHB_Research Adult stem cells. CRISPR in Organoids. Enteroendocrine cells.
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 science.org/doi/10.1126/sc…
Our first 2025 paper! We discuss in @NatRevMCB how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer. Great work from our former and current tumor mechanobiology experts Vince Fiore & @almagro_jorge nature.com/articles/s4158…
Thrilled to see #SAVANA out in @naturemethods🥳 SAVANA detects haplotype-resolved somatic SVs and copy number aberrations (SCNAs) and infers tumour purity & ploidy in clinical samples using long-read sequencing with or WITHOUT a matched germline control 👇nature.com/articles/s4159…
Modular integration of epithelial, microbial, and immune components to study human intestinal biology. Amazing team project with @_RubenL_, Marius Harter, @CY_Qianhui_YU, @mike_nikolaev, @TheLutolfLab, Nikolche Gjorevski, and many others @IHB_Research biorxiv.org/content/10.110…
New insights into the actions of GIP agonism vs. antagonism on food intake and body weight in mice from Timo Muller and colleagues #weightloss #obesity @NatMetabolism @TimoMueller_IDO @MatthiasTschop nature.com/articles/s4225…
We are searching for 2 talented MSc students to join the group! If you are interested in using advanced organoid models to study regulators of intestinal differentiation or nutrient uptake, please apply! go.roche.com/skt2b and go.roche.com/wf7hj @IHB_Research
A new peptide, BRINP2-related peptide (BRP) administered pharmacologically, reduces food intake and exhibits anti-obesity effects in mice and pigs without inducing nausea or aversion. nature.com/articles/s4158…
Great pleasure to host @SItzkovitz at @IHB_Research. Exciting talk & discussions on spatial transcriptomics of adult tissues. Including promising translational applications of using shed intestinal cells for longitudinal profiling of homeostatic and diseased cell states!
A big thanks to @SItzkovitz of @WeizmannScience visiting #TeamIHB! We were fascinated to learn how spatial and shed cell transcriptomics of the human digestive tract can illuminate how single cells in mammalian tissues collectively achieve physiological goals.
We are searching for a Master's Student/Intern to join the group for 6-12 months to work on large-scale bioimage analysis of complex human model system data! Please send your CV to: [email protected] #IHB
iFlpMosaics are now published @naturemethods. A compendium of novel genetic tools and related methods for inducing and analysing genetic mosaics in a high-throughput manner. nature.com/articles/s4159… Tweetorial 👇
We updated our BindCraft preprint with lots of new exciting results! We release all our binder sequences and models, include more in silico analysis, novel design targets, and present AAV retargeting to specific cell types using de novo binders! biorxiv.org/content/10.110…
If you really love your protein of interest commit to a tattoo @ardemp
📢We are hiring a postdoctoral researcher 📢 Are your curious about the mechanisms driving metastatic spread? Do you have *bioinformatics* skills to help us unravel these mechanisms? We (@Bergerslab, @ColindaScheele) may have your dream job @VIB_CCB! jobso.id/k7cp
Only 2 weeks left to apply for our junior & senior group leader calls! Join us in Basel to do cutting edge basic and translational research on human disease. In a very collaborative environment, where you can leverage state-of-the-art human model systems and technology platforms.
📢Open call for Scientific Group Leads! #TeamIHB seeks stellar Junior & Senior scientists to start research groups on innovative and translational #HumanModelSystems. Expertise in #Immunology, #Neurology, #Ophthalmology, #Metabolism or #Oncology a➕! More go.roche.com/11jc8
The GLP-1 drugs we've got now are just the beginning. The gut nutrient cell sensors ( a cellular instead of a peptide hormone target) have considerable potential. Brief thread by @HansClevers on their new @ScienceMagazine paper
New @ScienceMagazine study in collab with @IHB_Research! We identified novel receptors on enteroendocrine cells (EECs) that regulate secretion of endogenous hormones. These harbor therapeutic potential for metabolic disease. Read the paper go.roche.com/m9hah or 🧵⬇️
Real fun collaboration between @_Hubrecht and @IHB_Research labs on 'nutrient sensors' in the gut, with multiple interesting follow up studies (e.g. - apart from a convenient surface marker - why do all EECs specifically express an immune ckeckpoint?)
New @ScienceMagazine study in collab with @IHB_Research! We identified novel receptors on enteroendocrine cells (EECs) that regulate secretion of endogenous hormones. These harbor therapeutic potential for metabolic disease. Read the paper go.roche.com/m9hah or 🧵⬇️
In case you are looking for an interesting/easy reading this weekend, how about some thoughts on in vitro human cell-based models cell.com/cell/abstract/… @CellPressNews @TheLutolfLab @TakebeLab
NEW! REVIEW @ChSchneider_PhD & colleagues on tuft cells in the intestine, immunity and beyond Link: nature.com/articles/s4157… Read-only: rdcu.be/dVhSO
Ready to establish your own research group at the Hubrecht Institute for molecular and developmental biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! hubrecht.eu/job/tenure-tra…
Super happy to share that our paper is published in @Nature today! We've discovered how the breast is protected against tumor initiation—though it comes at a cost. 📰Read all about it here: bit.ly/3MSxoa1 🏥@vib_ccb @Onco_KULeuven @NKI_nl @vanRheenen_Lab @BenSimons_Lab