Angelo Keramidas
@AngeloKeramidas
Researching ion channels.
1st individual gene mutation test for predicting risk of sudden cardiac death has been developed by Prof @VandenbergJamie + Dr @ChaiAnn_Ng. The collaborative research in @CircAHA will make a huge difference in how high-risk Long QT patients are cared for: smh.com.au/national/what-…
Resolving native GABAA receptor structures from the human brain | Nature doi.org/10.1038/s41586…
Publication alert 📢 Understanding paralogous #epilepsy–associated GABAA receptor variants 🤩 Our findings illustrate how gene family information may facilitate variant interpretation👍 Excellent work by @anthonykan1016, Ali Kusay and @NazaninAzarine1 👏 pnas.org/doi/10.1073/pn…
Asynchronous subunit transitions precede acetylcholine receptor activation | bioRxiv biorxiv.org/content/10.110…
Allways a pleasure to read these single channel studies. Congratulations to the authors.
At synapses, NMDA receptors convert presynaptically released glutamate into a synaptic signal. He & @LonnieWollmuth define the impact of various environmental factors & GluN2 subunit composition on the efficiency of rapid glutamate-induced channel opening hubs.la/Q02Zb4w20
I updated the blog post with a simple function to calculate the membrane voltage sag in Python. I also included an example of using the function within a loop to analyze multiple files. Hope you find it useful! spikesandbursts.wordpress.com/2022/05/13/pat…
We all enjoyed this project @AshvriyaT, @StingScience. The link to the paper is here: doi.org/10.1016/j.jbc.…
Researchers have uncovered the workings of ant venom by measuring electric currents through individual channels in cells to understand how it causes pain. @AngeloKeramidas 📷 Jonghyun Park
📰Excited to share our latest work just published in @NatureComms Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow nature.com/articles/s4146… 🧵
Wisedchaisri et al. describe structural basis for severe #pain caused by mutations in the voltage sensors of sodium channel NaV1.7. hubs.la/Q02RDhN30 📒 In our #Neuroscience collection: hubs.la/Q02RDnDv0 #SfN24
The TMEM132B-GABAA receptor complex controls alcohol actions in the brain: Cell cell.com/cell/fulltext/…
Thank you for the opportunity to contribute to this significant discovery. Congratulations to all the team, particularly Guohao. A fantastic outcome for all involved.
Congrats, Guohao!!! Thank you, @ghwang85 and the team！@dcast421 @AngeloKeramidas @Martin17436419 @wenyan_han @MiriamERM and X-less Shixiao Peng, Qingjun Tian, Lijin Dong and Yan Li! 10.1016/j.cell.2024.09.006 cell.com/cell/fulltext/…
So sad to hear that my wonderful PhD supervisor Shin-Ho Chung passed away last week. He made a huge impact on the ion channel community and will be sorely missed. His amazing BD movies will stay forever in my mind. #biophysics #AusBiophysics #ionchannel @BiophysicalSoc
“If academics generally had other prestige mechanisms they could refer to—such as actually reading the articles more carefully when making tenure decisions—they wouldn’t depend so much on the publishers.” Hi, hi, hi!!! So true! insidehighered.com/news/faculty-i…
"Voltage-dependent G-protein Regulation of CaV2.2 (N-type) Channels”: The 1st part of our team's "CaV2 trilogy" was just published in @scienceadvances! 🧵about how a human presynaptic channel consolidates ⚡️electrical, #Gproteins and #calcium signaling science.org/doi/10.1126/sc… 1/9
An ant venom peptide, Ta3a, binds to voltage-gated sodium channels, holds their voltage sensors in the activated (up) configuration to create a bilayer of fixed positive charges and mobile anions. No wonder ant stings are so painful……clever ants!! sciencedirect.com/science/articl…
We have a new paper for you: “Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel”. Here we found that the prototypical pentameric ligand gated ion channel can form stable tetramers and characterized it with cryo-EM/ET and molecular simulations.
Congratulations on a cool ion channel biophysics study.
Potassium dependent structural changes in the selectivity filter of HERG potassium channels | Nat Commun doi.org/10.1038/s41467…
Nav1.7 and Cholesterol: Our MD simulations & in-vitro patch clamp suggest that Cholesterol depletion increases Nav1.7 current densities and alters fast inactivation: doi.org/10.1016/j.ijbi…. Thank you Vishal Eswaran, Simone Albani and @G_Rossetti_ for the fruitful collab!
I had a lovely visit to @IMBatUQ and @QldBrainInst this week. Discussed lots of great brain science and got to see superstar @RosemaryJCater new lab! Thanks to @AnggonoLab for the invite and hosting me. @DehorterLab @PraneshPadmana1
It was my absolute pleasure to host @renaemryan1 for the Centre for Chemistry and Drug Discovery seminar @IMBatUQ this week! She shared such beautiful research and it was so fun to have my PhD advisor get to know my new academic home!
Late to the party, as was published in June, but happy to be part of this work by G.Berecki, S.Petrou and others, in @Brain1878. Not all SCN2A variants causing neonatal-onset DEE are straightforward gain-of-function: a finding with treatment implications. academic.oup.com/brain/advance-…