Journal of General Physiology

#CallForPapers 📣 We invite submissions on the topic of @sgpweb’s 2025 Meeting “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (hubs.la/Q039qf0v0) Guest Editors are @carlson_lab & @ZhaozhuQ 👉 hubs.la/Q039q1S20

📣#CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology and Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health and Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉hubs.la/Q03y2ggP0

#CallForPapers 📣 We invite submissions on the topic of @sgpweb’s 2025 Meeting “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics!” with Guest Editors @carlson_lab & @ZhaozhuQ! Learn more: hubs.la/Q039qpPw0

Colleen Clancy @ucd_physiology highlights the comprehensive meta-analysis by Clerx et al. (hubs.la/Q03xvjrh0 ) that challenges long-standing assumptions about data interpretation, data comparison, and electrophysiological data used to develop models. hubs.la/Q03xvkNX0

Clerx et al. @UniofNottingham present variability in reported midpoints of activation and inactivation for the cardiac fast sodium current, INa, show the correlation between these midpoints, and discuss possible experimental sources of variability. hubs.la/Q03xvdTQ0

Single-molecule imaging provides a high spatial resolution of fluorescent ATP binding to myosin within cardiac myofibrils. Pilagov, Steczina, Naim, Kad et al. @UniKent study PKA phosphorylation and a haploinsufficiency-causing mutation from human tissue. hubs.la/Q03w2M9f0

Our July issue is here! hubs.la/Q03vJ9tM0 The cover image highlights the voltage-gated sodium channel NaV1.8 and its targeted drug Journavx, illustrating their role in pain perception and therapeutic intervention. From Wood et al. hubs.la/Q03vJccH0

#CallForPapers on the topic of @sgpweb’s 2025 Symposium “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” - we welcome submissions on diverse membrane protein families involved in transporting anions 👉 hubs.la/Q039qFSz0

🧑‍🔬🎙️ Did you know that JGP supports video summaries of your research? When you publish with JGP, you can reach more of your community by submitting a short video! 🎦 See our guidelines: hubs.la/Q03vr0vx0 ▶️ Watch video summaries from our authors: hubs.la/Q03vr6qc0

Great to see that our recent work was highlighted in the Research News @JGenPhysiol !

Very happy that our science-literature synergism resulting from the worldwide sodium channel conference #WSCC24 in Grindelwald is out. Ever thought about how the words you are using to describe your results shape how you approach your science? I hope you enjoy reading!

New work (@SeongWon_HAN et al hubs.la/Q03sDVvM0) reveals that glycerol storage increases the titin-based stiffness of muscle fibers, suggesting this commonly used method should be avoided by researchers interested in the passive properties of muscle hubs.la/Q03sDXCv0

Danicamtiv & omecamtiv mecarbil are second- and first-generation myotropic sarcomere activators intended to treat patients w/ #HeartFailure with reduced ejection fraction. New work by Holmes & Stelzer directly compares the drugs' in vivo cardiac mechanisms hubs.la/Q03sDVF_0

📣#CallForPapers on the topic of @sgpweb’s 2025 Symposium “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (hubs.la/Q039qcYs0) Learn more and submit your research 👉 hubs.la/Q039qd-X0

Gong, @JennOligoMyelin, Abrams et al. present two novel, disease-causing genetic variants of #connexin 47. In vitro assays and MD simulations reveal unique mechanisms that relate connexin 47 mutations to severities of Pelizaeus–Merzbacher-like disease 1. hubs.la/Q03rtFRz0

#CallForPapers 📣 We invite submissions on the topic of @sgpweb’s 2025 Meeting “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (hubs.la/Q039qwtJ0) Guest Editors are @carlson_lab & @ZhaozhuQ 👉 hubs.la/Q039qf0F0

Metaphors shape how we communicate & understand science, from genetic blueprints to molecular gates. Hull and @LampertLabRWTH explore their role in the sodium channel fast inactivation mechanism-accessible to readers without a linguistics background. hubs.la/Q03qrsNw0

Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N-termini, say Yu Zhou, Xiao-Ming Xia, and @LingleChris @washumedicine: hubs.la/Q03pZSQV0: hubs.la/Q03pZQTB0 #Biophysics #MolecularPhysiology #IonChannels #BKChannels

“By identifying & promoting good science, treating authors with decency and respect, and ensuring quality of peer review, editors nurture the reputation and quality of journals.” Read the editorial by our sister journal @LSAjournal's @timisstuck: hubs.la/Q03nyMZH0

Obscurin deficiency leads to compensated dilated #cardiomyopathy and increased #arrhythmias, say Josè Manuel Pioner, Enrico Pierantozzi, Cecilia Ferrantini, Vincenzo Sorrentino et al. @Uni_firenze @unisiena hubs.la/Q03mtGRL0 #Arrhythmia #Genetics #Cardiology

#CallForPapers on Chloride Channels and Transporters! Topics of interest include chloride channel and transporter structures and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 hubs.la/Q039qh3J0