Saei Lab

Honored to be one of the four awardees of the Novo Nordisk Excellence Emerging Investigator Grant - Endocrinology and Metabolism 2025. I am incredibly grateful to the review committee for recognizing the potential impact of our research and to the @novonordiskfond Foundation for…

Congrats to Daniel @Dan__Groom where he shows in human ART1, binding of NAD+ and l-arginine-like substrates happen through a random mechanism. Followed by chemistry in a ternary complex, and ordered release of the products #enzymes #kinetics #NAD #ADPribosylation #PARP👇

🚀 We're looking for a postdoc to join an exciting project between the Chronobiology Lab (Paul Petrus) and Saei Lab at Karolinska Institutet! We're looking for someone with skills in endocrinology, proteomics and bioinformatics. Apply by May 8. ki.varbi.com/en/what:job/jo…

Looking at bioinformaticians’ profiles these days, you'd think everyone has decades of experience in cutting-edge single-cell and AI-driven bioinformatics. But something’s missing… 👇

Invited to the Cancer Research Horizons and Oncode Institute to Hepatocellular Carcinoma Think Tank in London. Identifying and progressing novel therapeutic approaches in liver cancer! Hope to connect with great scientists in the area!

Amazing work, the type of which will accelerate drug discovery: nature.com/articles/s4158…

The critical role of the protein corona in enhancing the depth and precision of protein quantification in plasma proteomics: …iencejournals.onlinelibrary.wiley.com/doi/10.1002/pm… @MahmoudiLab @AmirAta8

1/ Over a century ago, scientists uncovered a curious link between the gut & the pancreas. This sparked decades of research, culminating in one of the greatest medical breakthroughs. This is the story of GLP-1 that I would like to share. 🧵

Postdoc position in our lab, focusing on the role of oncometabolites in liver cancer using a variety of cell biology, biochemistry and proteomics techniques. Freshly funded by the prestigious @Cancerfonden Please apply or share. ki.varbi.com/en/what:job/jo…

In this work led by @mzw1399 , we present the one-pot time-induced (OPTI)-PISA assay, for automated target identification across the entire proteome. OPTI-PISA significantly reduces sample requirements to sub-microgram levels, suitable for NanoProteomics. pubs.acs.org/doi/10.1021/ac…

I’m excited to share our latest study in @nature on this novel compound called Gliocidin, that targets glioblastoma (#GBM), the most malignant brain tumor. #drugdiscovery #cancer #cancermetabolism @GSKGradSchool @MSKCancerCenter nature.com/articles/s4158…

Thrilled to share our approach for language model-guided discovery of unknown mammalian metabolites: DeepMet. We’ve now used this approach to discover ~50 new human and mouse metabolites! biorxiv.org/content/10.110…

News coverage from Karolinska Institutet on our latest paper: Very happy with what we have achieved so far with @MoriMahmoudi lab. news.ki.se/new-method-for…

Hexokinase 2 senses fructose in tumor-associated macrophages to promote colorectal cancer growth dlvr.it/TG4KSC

I am hiring a Research Assistant (Microbiology)! We are expanding our team at @UccMicrobiology and @Pharmabiotic studying nutritional- and microbiome-based approaches to improve human health . Search 080852 on ore.ucc.ie for full details. Deadline 8th November 2024.

News in Proteomics Research blog post | Gain of cysteine missense mutations in both disease and healthy(?) human tissues?!? proteomicsnews.blogspot.com/2024/10/gain-o… --- #proteomics #prot-other

This may be obvious to some but I'm now convinced: fierce competition for grants and papers is leading to low societal ROI (return on investment). Why, when competition should mean only the best-formulated and executed work is accepted for funding and high-profile publication?