Jack Zhang Lab
@zhang_lab
Jack (Kai) Zhang Lab at Yale University Intracellular Transport, Cell Motility, Mitochondria, Cryo-EM/ET Methodology -- Cellular Structures, Life & Health
Check out these awesome high-resolution in situ structures of the translation machinery! Nearly ALL states at better than 3.0 Å!
Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/sh…
One UK institute has produced a dozen Nobel laureates and biomedical breakthroughs across the board. How does Cambridge’s Laboratory of Molecular Biology do it? go.nature.com/4cncxXi
First day in New Haven for Ailong, and we're welcoming his family with a BBQ party together with Yong Xiong, Steven Tang, Hanting Yang in my backyard. Just arrived, but crazy scientist says he will already start working officially tomorrow!

We asked @ProfMonaSingh @cenksahinalp @Jianyang_Zeng @vivianstats @ckingsford Qiangfeng Zhang (@frcbs_Tsinghua) @przytycka @LabWelch @jmuiuc @lab_berger about how AI impacts algorithm development in computational biology cell.com/cell-systems/f…
Forcing an outstanding young scientist away ... x.com/i/status/18053…
Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/sh…
This wonderful international symposium on the future of #structural biology, organized by the world's most influential biologist Yigong Shi and his colleagues, including my #cryoEM friend Alexey Amunts, stands apart from all other meetings by actively inviting many promising…
Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/sh…
Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I | Science science.org/doi/10.1126/sc…
This week in Nature: Complex system - AlphaFold3 powers predictions of protein-molecule interactions Browse the full issue: nature.com/nature/volumes…
Strategic disruption of #cancer’s powerhouse: precise nanomedicine targeting of #mitochondrial #metabolism jnanobiotechnology.biomedcentral.com/articles/10.11…
This landmark #ReviewedPreprint represents “the most significant breakthrough in membrane and secretory biogenesis in recent years.” ‘Structural analysis of the dynamic ribosome-translocon complex’ elifesciences.org/reviewed-prepr…
Structure and topography of the synaptic V-ATPase–synaptophysin complex | Nature doi.org/10.1038/s41586…
A dad’s sperm records his diet — and this record affects his sons’ metabolism go.nature.com/4bLugYd
A Dialogue Between the Academic and Asian American Communities and the FBI will happen in two days! @BakerInstitute @RiceUniversity @AFAYale Please register for online or in person meeting and submit your questions by tomorrow! bakerinstitute.org/event/dialogue…
Nature research paper: High-resolution in situ structures of mammalian respiratory supercomplexes go.nature.com/454JPHV
BREAKING: Yale University announced on Wednesday that Maurie McInnis, the current president of Stony Brook University, will become Yale's 24th president. McInnis will be Yale’s first female president to serve in a non-interim capacity. yaledailynews.com/blog/2024/05/2…
I was reading 2023 Nobel laureate Katalin Kariko's book, Breaking Through. She was brutally honest about the academic system in US. And, here is an example section from her book.