Zane Koch

WHY DOES THE EPIGENETIC CLOCK TICK? While money has been poured into developing therapies to reverse the epigenetic clock (@altos_labs 🤑), why the epigenome changes with age at all is unclear. In @NatureAging today, we suggest a potential driver: somatic mutations.

Meet the 1,000th STAY participant: Winston! We've officially enrolled ONE THOUSAND DOGS in our LOY-002 lifespan extension study + we are upping enrollment to 1,300 dogs! this study will definitely quantify lifespan extension + quality of life improvement from our lead drug

Someone should build AdRL: - client describes what they want to advertise - AdRL generates prompts instructing veo3 on ads to generate - ads are auto-deployed to socials - based on the performance of each ad, AdRL updates the veo3 prompts to create new round of videos - 🔁

despite the hype, most everything in this paper has been shown by other groups years ago ❌ reprogramming via a single gene: 2023 (@amplesa bioRxiv 2023.11.13.566787) ❌ epigenetic clock reversal: 2020 (@SebastianoLab PMID: 32210226) – not a great metric for comparing…

a compiler is agnostic to the beauty of code, while the human brain compiles beautiful and ugly writing completely differently

its interesting to me that ai still feels so much more useful for programming than scientific writing i think this is because in writing its not enough to just convey the information, i also want to do so aesthetically. but as long as code gets the job done i'm happy

What if the path to slowing aging wasn’t a drug, but replacing worn out parts? Our new paper out today in @NatureAging shows how this could one day work. We map a unified framework—from scaffolds & bioprinted tissues to pacemakers, xenotransplants & brain machine interfaces—for…

theres dozens of stories every week now about people finding miracle cures for lifelong conditions with LLMs I think what’s going on here is much weirder than people think:

savage

To understand age-related disease, we must rely on human data. Gaps in human bio data bottleneck the development of impactful treatments and biomarkers. Long piece about what data is missing to make biomarkers that enable a step-change in age-related drug dev. Link and thread:

I love 'n of 1' experiments like this but I was left wanting a quantitative comparison between the score of each sleep tracker and @karpathy's self-reported feeling in the morning. So for the 14 days with a note of how he felt in the morning, I asked o1 to convert these into a…

Results presented in default matplotlib/seaborn/ggplot colors are immediately suspect

Now online, the main paper from my postdoc! A huge thank you to my coauthors, the Adams lab, and Peter @AdamsBioAging nature.com/articles/s4146…

give a man a drug to double his lifespan, and he’ll live twice as long give a man a biomarker able to predict a drug’s effect on lifespan, and he may double it again and again…

Loyal’s drug for senior dog lifespan extension drug LOY-002 has completed its FDA efficacy package (RXE) We are on track to hopefully bring the first longevity drug to market *this year* Thanks @lisabonos + @washingtonpost for the exclusive

cursed

high altitude training in a pill? next-level anti-oxidant? so cool

1/ 🚀 Excited to announce the release of our LongBio Report 2025 —comprehensively profiling the leading companies in longevity biotechnology. This is your guide to understanding the future of healthy lifespan extension. 👉Read the report:  healthspancapital.vc/longbio-report…