Prof Steve Horvath

Your DNA doesn’t dictate your destiny but it offers a pretty good forecast. An epigenetic clock named after the Grim Reaper is still the best at predicting death. In a massive study of 19,000 people in Scotland, the GrimAge clock was the best predictor of who would die over the…

How to modulate biological aging (body-wide, epigenetic) —Obesity accelerates jamanetwork.com/journals/jaman… —Exercise slows thelancet.com/action/showPdf… @TheLancet w/ @prof_horvath

About a year ago, at @ARDD_Meeting I proposed to @DomiWilczok on stage. I think it was the best year of my life. This year, I can't wait for the next ARDD - it will be epic. I just hope that we will see another couple or two forming to go after the longevity as the lifelong quest…

Disappointing results continue to accumulate in longevity research regarding efforts to remove or replace aged blood plasma in humans. The removal of old plasma (via plasmapheresis) was thought to eliminate pro-aging factors. In Borsky et al. (2025), healthy middle aged adults…

Challenging a longevity dogma in muscle aging. Validated epigenetic clocks (pan-mammalian and muscle-specific) reveal a surprise: an 85% drop in NAD⁺ in mouse muscle leaves epigenetic age unchanged. Muscle structure, function, and mitochondria stay strong: NAD⁺ loss ≠ muscle…

Can senolytics slow aging? Recent clinical trials and the largest mouse study of senolytics to date have failed to support this notion, raising questions regarding the future of senolytics as an anti-aging therapy. The latest @NatureBiotech 🚨 1/3 nature.com/articles/s4158…

☀️ Summer’s here and so is the momentum for our 2025 Biomarkers of Aging Conference! Our Conference team is in the midst of finalizing two full days of high-impact programming, spotlighting cutting-edge progress in aging biomarkers and offering insights into how these…

Plasmapheresis may backfire? 🚨 A new study in healthy adults found no anti-aging benefits after 4/8 rounds of plasmapheresis—instead, some aging markers went up. #Longevity #AgingScience By @BorskyMd, @prof_horvath, et al. nature.com/articles/s4159…

Gorgeous paper scientifically and artistically. Congrats to the team which included the Beijing Institute of Genomics, the Beijing Municipal Geriatric Medical Research Center, Juan Carlos Belmonte & @prof_horvath 👏👏 cell.com/action/showPdf…

“ER-100 [an epigenetic age reversal drug candidate] has demonstrated safety & efficacy in multiple pre-clinical animal models of disease” and is now heading into human clinical trials 👏 genengnews.com/topics/transla…

Thanks Steve and built on the shoulders of the methylation clocks, your manuscript in T-shirt form for our celebration today!

Genuine epigenetic rejuvenation in primary cells has long been the holy grail. A groundbreaking preprint reveals that over-expression of a single (secret) gene overcomes this barrier: greatly reduced age estimates across in fibroblasts and keratinocytes according to validated…

Like an oil change for your blood: therapeutic plasma exchange (TPE) replaces old plasma with healthy fluid. Epigenetic clock analysis of a randomized controlled trial (N=42, adults 50+) found biweekly TPE with intravenous immunoglobulin (IVIG) most effective. Surprisingly, by…

Sincere apologies to everybody for my long silence concerning the "RMR1" study that we at LEV Foundation designed, and Ichor Life Sciences conducted, starting in early 2023. As of the last update I posted, only a few of the original 1000 mice remained alive, so there was really…

Self-rated deafness is linked to faster biological aging on two second-generation epigenetic clocks (GrimAge2, DunedinPoAm) even after adjusting for age, demographics, lifestyle and overall health. DNAm CRP, the GrimAge methylation proxy for C-reactive protein, mirrors this…