Michael Booth (@DrMikeBooth)

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Michael Booth@DrMikeBooth · Jun 23

We have developed an entirely new mechanism of action for gene knockdown -> trafficking of targeted mRNAs to the lysosomal, using lysosomal trafficking oligonucleotides (LyTONs)! Published in @ChemicalScience Led by @disha_kashyap_, with @milnetom68 pubs.rsc.org/en/content/art…

DrMikeBooth's tweet card. Antisense oligonucleotides (ASOs) can modulate gene expression at the mRNA level, providing the ability to tackle conventionally undruggable targets and usher in an era of personalized medicine. A...

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Michael Booth@DrMikeBooth · Mar 12

We’ve integrated DNA nanotech into targeted protein degradation! Our oligoPROTACs act like small mol PROTACs but can be turned “OFF” — exciting alternative to pro-drug based activation for reducing toxicity! @DrMikeBooth @milnetom68 @chem_in_cells @OxfordChemistry @MRC_WIMM

MMichael Booth@DrMikeBooth · Mar 12

New preprint 🎇 We developed oligonucleotide PROTACs (OligoPROTACs), which show comparable activity to small molecule equivalents - but can be *switched off*, using DNA nanotech, to restore protein levels! Last of @disha_kashyap_'s trilogy! @milnetom68 chemrxiv.org/engage/chemrxi…

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Michael Booth@DrMikeBooth · Mar 12

We have engineered lysosomal trafficking-ASOs (LyTONs)! Novel mechanism of gene knockdown🧬 LyTONs don’t need RNase H recruitment — work as well/better than state-of-the-art gapmers! #RNAtherapeutics @DrMikeBooth @milnetom68 @chem_in_cells @OxfordChemistry @MRC_WIMM

MMichael Booth@DrMikeBooth · Mar 7

🚨 Preprint alert 🚨 We have developed an entirely new mechanism of action for ASO gene knockdown -> lysosomal trafficking 🧬! Works with non-DNA ASOs (unlike RNase H mech) and higher activity than corresponding gapmers! Led by @disha_kashyap_ @UCLChemistry @OxfordChemistry

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Michael Booth@DrMikeBooth · Mar 12

New preprint 🎇 We developed oligonucleotide PROTACs (OligoPROTACs), which show comparable activity to small molecule equivalents - but can be *switched off*, using DNA nanotech, to restore protein levels! Last of @disha_kashyap_'s trilogy! @milnetom68 chemrxiv.org/engage/chemrxi…

CChemRxiv Bio and Med Chem@chemRxivBiochem · Mar 11

DNA-programmable Protein Degradation: Dynamic Control of PROTAC Activity via DNA Hybridization and Strand Displacement ift.tt/nBJTCpo #chemrxiv_biochem

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Michael Booth@DrMikeBooth · Mar 7

🚨 Preprint alert 🚨 We have developed an entirely new mechanism of action for ASO gene knockdown -> lysosomal trafficking 🧬! Works with non-DNA ASOs (unlike RNase H mech) and higher activity than corresponding gapmers! Led by @disha_kashyap_ @UCLChemistry @OxfordChemistry

CChemRxiv Bio and Med Chem@chemRxivBiochem · Mar 7

Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking ift.tt/jU35D49 #chemrxiv_biochem

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Michael Booth@DrMikeBooth · Feb 18

Massive congratulations to @DrZoeWaller for winning the 2024 @RoySocChem Chemical Biology and Bioorganic Lectureship - today, giving her fantastic award lecture at the 2025 RSC CBBG Forum, in Bristol 🥳🏆

DrMikeBooth's tweet image. Massive congratulations to @DrZoeWaller for winning the 2024 @RoySocChem Chemical Biology and Bioorganic Lectureship - today, giving her fantastic award lecture at the 2025 RSC CBBG Forum, in Bristol 🥳🏆

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Michael Booth@DrMikeBooth · Jan 10

Still time to apply for this #PhD project to join my group and @DrMikeBooth group at @UCLChemistry Project is part of #CDT in #Engineering Solutions for #Antimicrobial #Resistance App #Deadline: 26th Jan CDT #OpenDay : 14th Jan on Zoom More info 👉 shorturl.at/tmfBK

GGuido Bolognesi@guido_bolognesi · Dec 5

#Phd project available to join my group and @DrMikeBooth's group at @UCLChemistry on the #CDT in #Engineering Solutions for #Antimicrobial #Resistance to work on electrokinetic and nucleic acid technology for lateral flow assays (ucl.ac.uk/london-nano/cd…) App Deadline: 26/01/25

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Michael Booth@DrMikeBooth · Dec 19

Read our review on next-generation covalent modifications for nucleic acid therapeutics! 🧬💊

MMichael Booth@DrMikeBooth · Dec 18

We just published a review in ACS Bio & Med Chem Au on the state-of-the-art and future of covalent nucleic acid conjugates as therapeutics 🧬💊! Led by @disha_kashyap_ @ACSBioMed @ACS_DivBioChem @UCLChemistry @OxfordChemistry @chem_in_cells pubs.acs.org/doi/10.1021/ac…

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Michael Booth@DrMikeBooth · Dec 12

#ASO nuclear localisation unlocked via (+)-JQ1 conjugation! We’ve enhanced the splice switching activity and RNase H-recruitment of antisense oligonucleotides🧬 One of my main DPhil projects #RNAtherapeutics! @DrMikeBooth @milnetom68 @chem_in_cells @OxfordChemistry @MRC_WIMM

MMichael Booth@DrMikeBooth · Dec 5

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_ @milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry chemrxiv.org/engage/chemrxi…

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Michael Booth@DrMikeBooth · Dec 8

JQ1 4EVA! @jaybradner @JunQiLab

MMichael Booth@DrMikeBooth · Dec 5

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_ @milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry chemrxiv.org/engage/chemrxi…

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Michael Booth@DrMikeBooth · Dec 7

Fascinating work showing that the covalent addition of a nuclear importing compound, JQ1, to therapeutic oligonucleotides enhances their activities by enhancing nuclear penetration.

MMichael Booth@DrMikeBooth · Dec 5

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_ @milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry chemrxiv.org/engage/chemrxi…

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Michael Booth@DrMikeBooth · Dec 5

Super congratulations! 👍👍👍

MMichael Booth@DrMikeBooth · Dec 5

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_ @milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry chemrxiv.org/engage/chemrxi…

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Michael Booth@DrMikeBooth · Dec 5

Really cool design: sending ASO to nucleus via conjugating JQ1.

MMichael Booth@DrMikeBooth · Dec 5

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_ @milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry chemrxiv.org/engage/chemrxi…

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Michael Booth Retweeted

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Guido Bolognesi@guido_bolognesi · Dec 5

#Phd project available to join my group and @DrMikeBooth's group at @UCLChemistry on the #CDT in #Engineering Solutions for #Antimicrobial #Resistance to work on electrokinetic and nucleic acid technology for lateral flow assays (ucl.ac.uk/london-nano/cd…) App Deadline: 26/01/25

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Michael Booth@DrMikeBooth · Dec 5

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_ @milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry chemrxiv.org/engage/chemrxi…

DrMikeBooth's tweet image. We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer!

Preprint led by @disha_kashyap_
@milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry chemrxiv.org/engage/chemrxi…

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Michael Booth@DrMikeBooth · Nov 27

Excited to be at @BiochemSoc Synthetic Biology UK 2024 #SBUK24 at the Sanger Institute near Cambridge! Going to give a little talk about our magnetic activation work 😊 will be posting on the bluer place... #biochemevent

DrMikeBooth's tweet image. Excited to be at @BiochemSoc Synthetic Biology UK 2024 #SBUK24 at the Sanger Institute near Cambridge! Going to give a little talk about our magnetic activation work 😊 will be posting on the bluer place... #biochemevent

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Michael Booth@DrMikeBooth · Nov 14

The annual @RSC_CBBG Forum is being held in Bristol next February! This is fantastic opportunity for new group leaders and postdocs in #chembio to talk about their science - oral abstract deadline is 6th December!!!

MMichael Booth@DrMikeBooth · Dec 5

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_ @milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry chemrxiv.org/engage/chemrxi…

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Michael Booth@DrMikeBooth · Nov 12

"Actually the term 'doctor' was originally used for doctoral degree holders and was co-opted by the medical field"

MMichael Justus@mhjrad · Nov 12

Annoy a doctor in one tweet

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