Sophie Rogers
@synaptic_soph
Neuro PhD candidate @Penn in Corder lab! 🧠 How psychedelics affect neural circuits & behavior. Co-Host of PsychExchange Podcast. http://tinyurl.com/bdwd6b79
Thrilled to share that my first paper is officially out in its final form!! Thank you so much to my incredible thesis advisor @FlyBottleEscape and committee advisor & collaborator Liz Heller 🤩
🧠 🍄 ⚡️🐭 Now published in @NatureNeuro … Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility nature.com/articles/s4159…
Exciting new stuff coming soon!! Building on my brilliant colleagues' work (@_JustinGJames et al), I built a K-Means-GLM to show ACC dynamics track both sparse spontaneous behaviors and the slower latent states they express... stay tuned for effect of chronic pain & analgesia!
🚀 New LUPE Feature: Pain State Model—mapping pain dynamics over seconds to minutes ⏱️ 🔹 6 unique states identified from 316,488 observations 🔹 State classification offers data-driven insights into chronic pain 🔹 Syncs with neural activity recording tech @Inscopix 🐭🧠🔬🤖
🧠 Now published in eNeuro @SfNtweets AxoDen: An Algorithm for the Automated Quantification of Axonal Density in Defined Brain Regions eneuro.org/content/12/6/E…
🧠🐁 Interested in a quick / reliable / reproducible tool to quantify your fluoresently-tagged axons ? Check out AxoDen, a no-coding-needed web app and downloadable GUI ... Designed + developed entriely by the amazing Raquel Adaia Sandoval Ortega @adaiasand 🙌
New research out in @NatureNeuro finds that psilocybin-enhanced fear extinction is linked to the bidirectional modulation of cortical ensembles ft @FlyBottleEscape, @synaptic_soph (@PennPsych/@PennMINS/@PennAnesthesia) & Elizabeth Heller (@PennSysPharmATT) nature.com/articles/s4159…
They aren’t going to do their jobs like they say. They’re going to use you and the American people to fit their agenda, just like everyone before them, but this time it’s scary bc their agenda is to become the most powerful people in the land at the expense of everyone else.
Tens of thousands of Pennsylvanians marching into the night and towards the polls, for freedom, truth, dignity, justice, and our future to our blue anthem. Can’t wait to vote for you @KamalaHarris
Pizza and beer Fridays in lab >>>
Ending Spring(winter😂) cleaning day in the Corder Lab with beer, pizza, and a toast to @PennNGG PhD Candidate Lisa Wooldridge for submitting her first-author paper on the central amygdala in opioid dependence!
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💪🏽💪🏽💪🏽 Huge congrats to @synaptic_soph for completing their 100th miniscope surgery! 🧠🔬 An incredible milestone
Proud of my incredibly brilliant friend and colleague @Adrienne_Jo_ - @PaloSantoFund is so lucky to have her 😍
We’ve always been proud to have @Adrienne_Jo_ on the Palo Santo team, but from now on we’re especially proud to call her DOCTOR Adrienne Jo! She has successfully defended her pharmacology PhD thesis (University of Pennsylvania) after years of hard work and perseverance.
5th year PhD student rereading first year candidacy exam.
Words can’t express how proud I am of Dr. @Adrienne_Jo_ what a magical day to be present for 😍
Incredibly proud of Adrienne’s stunning work, rigor, kindness and tenacity… she put together an amazing body of work, and I wish all the best in her next career in California … Congrats on an amazing defense, Dr. Jo !!! 🔥🍾🙌🏼🐭🧠 music.apple.com/us/album/avril…
I think the biggest meta level issue with psychedelic medicine & science, manifested in countless ways, is that it's an unprecedented virtue signaling machine. The spiritual effects are very effective at providing cover for unethical behavior.
Jess’s last day @PennMedicine !! 🥲 Farewell to an amazing scientist! 🎓 Her hard work, curiosity, and passion have left a lasting impact on the lab. Wishing Jess all the best in her next science adventure—your future is bright! 🌟