Jeff Nivala
@jeffnivala
technomolecularfabulous. Assist. Professor at the University of Washington. @uwcse @UWMolES co-director @datamolecules
Announcing the Molecular Programming Decadal Flightplan! July 21–23 2025 | Seattle, WA We’re organizing a field-wide, community-driven conference to chart a 10-year strategic vision for molecular programming and we need you to help us lead it. Apply Now: mpflightplan.com/apply-now
Hybridization-encoded DNA tags with paper-based readout for anti-forgery raw material tracking | Nature Communications nature.com/articles/s4146…
What to agument your favourite protein with new functionalities? We've got a #biodesign workflow to help with that! In work led by Georgie Hau Sørensen we present SIMPLIFE that blends biophyscial and #ML models to extend biology in useful ways. #synbio doi.org/10.1101/2025.0…
Do you work with recombinases?🛠️🧬In the latest from my lab, Veronica Greco shows how @nanopore sequencing paired with automated liquid handling provides the perfect platform for characterising these systems at scale! #synbio doi.org/10.1101/2025.0…
Just a few months ago, the Baker and Garcia labs released con-concurrent preprints with incredible results. They designed de novo miniproteins that bound specific peptides presented in MHC-I. Now let me show how you can use BindCraft at @AriaxBio to do the same thing.
Looking for a PhD ? I have a fully funded one for UK nationals on engineering gene circuits in probiotic microbes. Will bring together a lot of existing stands of #synbio research in my group and push towards some exciting applications! Start date will be Sept 2025. Pls RT
Emerging protein sequencing technologies: proteomics without Mass spectrometry?: Expert Review of Proteomics: tandfonline.com/doi/full/10.10…
Had a great time on the @Agents_of_Tech podcast! Dreaming about 'data forests' of the future reminds me that biology is technology youtube.com/watch?v=2dBgOH…
Genomics postdocs- deadline to submit to our April 15 symposium in Santa Cruz, CA, is NEXT SATURDAY (2/15)! Travel expenses covered for selected applicants ✈️😎🏖 Tag a colleague who is doing amazing research 🥼 Apply here: bit.ly/NextWave25
Six new retrons just dropped! See how we isolated these cool bacterial immune systems from the wild in our latest preprint. From soil to sequence, we uncover the operons of these novel retrons and their phage defense properties. As a bonus, we repurpose them for genome editing 🧬
We just posted a new preprint where we found retrons in bacteria out in the real world, in dirt and water. We describe the first retrons in a handful of new species, show how they defend against phages, and use them to edit genomes. Read about it here: biorxiv.org/content/10.110…
Oh dear.
New preprint claims that most existing DNA language models perform just as well with random weights, suggesting that pretraining does nothing (Mistral & DNABERT-2 look like exceptions). We need better DNA language models.
This rate of validation suggests that antibodies should be considered non-specific until proven otherwise: 357 validated out of 1,124 tested. .
We’re excited to announce our first speaker of London Calling 2025 @jeffnivala will share their groundbreaking ‘proof-of-concept' method showcasing the capability of #nanopore sequencing to read #polypeptide strands – a major step forward in protein analysis.…
We did gene therapies like this in our garage almost 10 years ago Tbh my Netflix special, Unnatural Selection, was better Also, the company in prospera is the same scam company in my Netflix special
Watched the @bryan_johnson documentary DONT DIE last night. Go give it a watch!!! The trip to Prospera for gene therapy is very eye-opening. What if the follistatin gene Tx Bryan takes increases muscle mass and is safe? Is that a trillion dollar product? It's crazy that…
Eat your heart out, Gutenberg @AsimovPress book #2, encoded in DNA, available now for pre-order. One of the coolest projects I've ever seen unfold. Huge thanks to @catalogtechinc, @imagene_biotech, and @plasmidsaurus for making this possible, and @jasonjoyride for the epic vid
Our second book is now available for pre-order. 🎉 Embracing the book's technology theme, we did something special: We encoded the entire book into DNA & packaged it into stainless steel capsules, where it will live for tens of thousands of years. 1,000 copies were made... 🧵