Semil Choksi

We thought there wasn't much new to learn about the cell cycle. Turns out we were wrong! Our paper (out today @Nature) identifies a novel alternative cell cycle that regulates differentiation, not cell division. tinyurl.com/4a6yeuke. 1/10

EXCITED to unroll this 🧵 on our new story on the metabolic licensing of animal development... How did we even get here..? shorturl.at/vuCIh Early embryo is thought of a pre-set machine that's set to go once it's fertilized - check out this gorgeous 📽️from Phil Keller!

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)

Please read and critique our new paper on the genetic determinants of human kidney function @NatureGenet: rdcu.be/dTwye We combined GWAS with CNN and CRISPRi to go from loci to target genes. This roadmap may be useful to others uncovering genes underlying human traits.

Check out this nice writeup of our recent paper and the field at large. @WalentekLab identifies some of the most interesting outstanding questions!

The 2024 Santa Cruz Developmental Biology meeting is just 9 days away and counting! Peruse the full #scdb2024 talk schedule, now online here: bit.ly/3yD1n26

Fibroblasts are everywhere in our tissue as structural cells, yet we are only beginning to understand them. Today in @Nature, we report that lung-specialized alveolar fibroblasts orchestrate lung homeostasis, inflammation, and fibrosis. 🧵👇(1/n) nature.com/articles/s4158…

UCSF scientists have unexpectedly discovered that the cell cycle - which enables cells, like stem cells, to divide – can also sprout cilia, or hair-like appendages, in the lungs. @semilc @reiterlab tiny.ucsf.edu/Zf4mZ1

Are you going? I know I'm applying!

After ~12 years of hard labor, lots of push back and excitement, we are pleased to present our paper showing a new mechanism for the many features of asthma that came out in Science today with an awesome review by Jeffrey Drazen and Jeffrey Fredberg.science.org/doi/10.1126/sc…