Elphege Nora Lab at UCSF

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)

In short, we investigated the impact of DNA methylation (5-methyl-CpG) on 1. CTCF promoter-enhancer looping and 2. Polycomb-associated H3K27me3. To our surprise, we found both regulatory mechanisms converge to modulate the expression of Zdbf2, @maxvcg ‘s favourite gene.

@elphegenoralab.bsky.social

Target gene responses differ when transcription factor levels are acutely decreased by nuclear export versus degradation Read this Research Article by James McGehee and Angelike Stathopoulos @Angela_Stathop @stathlab: journals.biologists.com/dev/article/15…

Ecstatic to share the first story from my post-doc, co-led with Megan Ostrowski, out now in final form (cell.com/cell/fulltext/…)!

Thrilled to share our new preprint, 'A genome wide code to define cell-type specific CTCF binding and chromatin organization'. biorxiv.org/content/10.110…

‘Human Peoples’ is out @PenguinBooks A genetic journey through how migrations, admixture (among humans and with Neanderthals and Denisovans), and adaptations to environmental pressures (climate, nutrition, pathogens) shaped our physiology and health today. amazon.co.uk/Human-Peoples-…

I’m excited to share the first preprint out of the Altemose Lab! This stems from a heroic effort by Dr. Matt Franklin @matt_franklin_ (who's on the job market!), who made surprising discoveries regarding some of the most mysterious regions of the genome. biorxiv.org/content/10.110…

🎉Excited to finally share that our new work (previously @biorxivpreprint) is now online at @Nature! A fantastic team effort with amazing collaborators. You can read the paper by using the following link: rdcu.be/dXQs7 A thread 🧵/1 nature.com/articles/s4158…

It’s a bit belated, but I am happy to share the latest work from our group, led by a very talented post doc in the lab, Tessa Popay @tessapopay with great support from the 4D Nucleome consortium, Rita Allen, and the Pew Biomedical Scholars. biorxiv.org/content/10.110…

We @YinShenLab are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk genes in human iPSC-induced excitatory neurons using CRISPR tiling deletion screening. biorxiv.org/content/10.110… 1/20

CTCF, just like any transcription factor, binds its target sites on and off. Turns out considering this dynamic is essential to explain chromosome folding patterns from Hi-C and microscopy, and how they rearrange upon tampering with cohesin. What an exciting manuscript! 👏

📢 New preprint from the lab! CRISPR-screening wizard 🧙 🧬 @TSchwammle figured out how different signals 🚦 are integrated at the Xist locus. See his tweetorial below. biorxiv.org/cgi/content/sh…

1 week left to apply to the open-rank faculty search for the UCSF dept. of Biochemistry & Biophysics All area of fundamental biology are welcome Reach out if you have any questions

After a massive team effort leaded by the incomparable @NicolaFestuccia I am really happy to share our freshly published @ScienceMagazine ms where we elevate Nr5a2 to the top of gene regulation in the morula. 🔥🔥🔥 Take a look at Nicola's description 👇! science.org/doi/10.1126/sc…