Joshua Siegel
@realJoshSiegel
Neuroscientist, Psychiatrist, Father, Human, Philomath. Good science is careful. Great science is playful.
This extraordinary psychedelic precision functional mapping dataset is now fully/freely available to all! All the info to access & use it in a newly published Nature Scientific Data Resource: rdcu.be/epxe7 Thanks to the incredible team who created it - Subha S, Rick…
After a high dose of psilocybin, the brain desynchronizes at a massive scale, causing loss of our sense of self, time, and space. This may drive the burst of plasticity caused by psychedelics. The next day, brain activity has largely returned to normal, but an echo remains – a…
The argument at GRC about drug classification got me fired up. As use of these drugs in the real world grows, it is crucial to use clear language. Ketamine (dissociative, NMDA), LSD/psilocybin (classic psychedelic, 5HT2A), MDMA (empathogen/stimulant) have DIFFERENT primary…
Dispatch: The Neurobiology of Psychedelics Gordon Research Conference (Part 1) 200 psychedelic scientists met in Rhode Island to discuss the field via the first Gordon Research Conference on psychedelics. Read more: psychedelicalpha.com/news/dispatch-…
Well, this is a big development...
RFK Jr. Says Access to Psychedelic Therapies to Happen Within 12 Months He was responding to a question from Rep. Dan Crenshaw (R).
Anyone going to Psychedelic Science 2025 in Denver? I'm on a panel - "Beyond the Blobs: Visualizing the Psychedelic Brain" - with a film maker (Ethan Goldwater) and he made an incredible video JUST for the panel.
🧠 How Psychedelics Rewire the Brain | Joshua Siegel, MD, PhD youtube.com/shorts/od_5P5X… via @YouTube
"Effects of Psilocybin on Clergy..." The fact that this study was able to happen is impressive. Seing the published results is just ... incredible. "participants rated at least one of their psilocybin experiences to be among the top five most spiritually significant (96%),…
Major praise to the @nyulangone podcast team. I expected just a little internal thing, but they did an AMAZING job digging into the science and creating a great show. Check it out - YouTube (full-length): youtu.be/h8Thc-BDvZ0App… Podcasts: podcasts.apple.com/us/podcast/nyu… Spotify:…
It's terrifying to watch a tyrannical power grab in America. But also ... kind of fascinating... in a twisted way. Really brings the history books to life, huh?
Incredibly fascinating talk by Mir Jalil Razavi! Cortical folding is driven by surface expansion. Tiny differences in cortical thickness and starting morphology drive patterning of the brain surface. This is crucial info to anyone who wants to localize brain function.…
On Wed., March 19, at noon, as part of our #radiology #research forum: "Multiscale Mechanics of Brain Folding in Health & Disorder," w/ Mir Jalil Razavi, assistant prof. of #MechanicalEngineering at @binghamtonu. Talk details: cai2r.net/training/radio… #biomaterials & the #brain
Vote for our Psilocybin study! statnews.com/feature/stat-m… Don't ask me why someone would make a March Madness for academic research. But they did. For the love of science, I guess.
Psilocybin generates psychedelic experience by disrupting brain network – WashU Medicine medicine.washu.edu/news/mushrooms…
Deeply deficient system Medicine is great at saving lives with surgeries, antibiotics and other emergency-type tools But it is ignorant around healing processes required to sustain optimal health We need a proper Science of Healing and a vehicle to deploy the resulting…
I keep thinking of this post. That desync essentially feels like death and this is when you see your primordial brain and all the imagery and symbolism. It’s like getting a peek at the underlying motivations that drive you unconsciously. It feels fleeting.
After a high dose of psilocybin, the brain desynchronizes at a massive scale, causing loss of our sense of self, time, and space. This may drive the burst of plasticity caused by psychedelics. The next day, brain activity has largely returned to normal, but an echo remains – a…
Excited to share this paper led by Broc Pagni Multidimensional Personality Changes Following Psilocybin-Assisted Therapy in Patients With Alcohol Use Disorder: Results From a Double-Blind, Placebo-Controlled Clinical Trial | American Journal of Psychiatry psychiatryonline.org/doi/10.1176/ap…
“Men may seem detestable as joint stock-companies and nations; knaves, fools, and murderers there may be; men may have mean and meagre faces; but man, in the ideal, is so noble and so sparkling, such a grand and glowing creature, that over any ignominious blemish in him all his…
Rigorously conducted clinical trials always include a placebo control. Give half the subjects a drug, the other half a placebo, and measure the difference between them compared to baseline. The whole idea here is to look for a pure "drug effect" that goes beyond the "expectancy…