Nick Jikomes
@trikomes
Neuroscience, endocrinology, evolution, behavior (PhD) | Origins of biological decay & vitality | Podcast & writing: https://linktr.ee/trikomes
I laid this out in more detail, in the context of seed oils, in this post:
This is a general trend. Production efficiency gains due to technology result in large surpluses. Corporations holding onto those surpluses then need to dream up ways to convince people to buy their excess supply. One technique you can use if you struggle with fake foods intake…
Interesting take. Is Bryan Johnson putting himself into a hypometabolic, torpor-like state for the same psychological reasons that women have historically developed eating disorders like anorexia or bulimia? Some combination of coping with anxiety + social contagion from peers?…
My wife just compared all this tech-adjacent extreme longevity focus in men to anorexia in women. A physical manifestation of anxiety and lack of control. And now I can't get the thought out of my head. Spot on.
Pre-treating people who have depression with naltrexone, an opioid receptor blocker, reduces the acute antidepressant effects of ketamine. The effect was apparently stronger in men than women. Many psychoactive drugs and medications show sex differences, which is why it’s…
2/ In a double‑blind, randomised crossover, 26 adults with MDD received 50 mg oral naltrexone or placebo before a 0.5 mg/kg ketamine infusion over 40 min - while we tracked Glx/tNAA in the anterior cingulate cortex via dynamic magnetic resonance spectroscopy.
In my podcast with anthropologist Eugene Moren he told me about how Inuits apparently prized rotting seal meat, eating it maggots and all. Humans have very acidic stomachs, in the range of meat-eating scavengers, with lower stomach pH than carnivores and non-scavenging…
Happy Friday! A mysterious chemical signature seen in the remains of Neanderthals might be explained if they snacked on a special culinary garnish: maggots. 🤢 go.nature.com/4olC1Lc
Interesting. Most of my life people have always said that “half of marriages end in divorce,” as a generalization. Turns out divorce rates vary quite a bit depending on what time period people got married. That’s not shocking, but what is surprising is… ~85% of marriages from…
You've all heard the Manosphere bros, feminist bloggers, & media midwits complain that '50% of marriages end in divorce'. Yeah, if you got married in the 1970s. But if you got married in the 2010s, over 85% of marriages lasted at least 10 years... and they're on track to have a…
That’s a very cool story even if you were never a wrestling fan as a kid.
Rest in Peace, Terry Bollea aka The Immortal Hulk Hogan 🕊️💐 To millions of little kids you were a childhood hero - myself included. In 1984, I gave you your “HULKSTER” headband back, in the locker room in Madison Square Garden - I was the lucky kid caught it when you threw it…
Well, all those salaries, benefits, and full-time administrative staff aren't going to pay for themselves. 🤷♂️
Americans now spend more on health care than groceries or housing, with health care accounting for approximately 20% of household expenditures, according to the New York Times.
Update: I have decided not to use this feature.
You mean, like, voluntarily paying more taxes?
You mean, like, voluntarily paying more taxes?
Venmo, PayPal users can now send money to the US government to help pay down $36.7 trillion national debt, per NYP
Interesting new work showing how the effects of ketamine on depression rates to the opioid system:
1/ Just out in @NatureMedicine : we show the opioid system modulates ketamine’s effects in major depressive disorder, with naltrexone pre‑treatment reducing acute glutamatergic activity and acute antidepressant effects. nature.com/articles/s4159…
If you weren’t already convinced that bisphenol A (BPA) is wreaking biological havoc, here is a new study showing that prenatal BPA exposure messes with brain development in rodents, leading to autism-like behaviors. To learn about the horrible effects of BPA, I highly recommend…
Why don't people living in cold, non-equatorial places get much vitamin D synthesis in the winter? Turns out, it's because they cover their skin with clothes, not because the sunlight can't stimulate vitamin D synthesis. Remove that clothing, and you can get vitamin D…