Souvik Bhattacharyya
@necrosignaling
Assistant Professor at @UTHealthHouston @UTHealthMMG; Bacterial behavior, Antibiotics, Bacterial Memory, Necrosignal; GGMU♟️📷 he/him
In other news, I'm beyond delighted to share that I'll be joining the Dept. of Microbiology and Molecular Genetics at UTHealth Houston as an Assistant Professor. @UTHealthMMG @UTHealthHouston @McGovernMed Without the support of the following incredible people, my journey from 1/5
AnnotIEM: novel tool for microbiome species-level annotation of 16S gene based microbial sequencing biorxiv.org/cgi/content/sh… #biorxiv_bioinfo
🚨New preprint from our lab! We map the RNA interactions in E. coli infected by lambda, revealing an RNA-driven regulatory layer in phage-host dynamics. We find a phage-encoded sRNA hijacking host replication machinery, impacting the phage cycle.#microbiology #phages @MeetingRna
Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle biorxiv.org/cgi/content/sh… #biorxiv_micrbio
Happy MicroBOOology 2! MID continued the Halloween spirit with a lab door decorating contest. The theme was "creepy crawlies". Congrats to the Lee lab for winning with the effects of a deadly parasitic infection. @jleelab_schisto
New preprint up! We sequenced hundreds of samples from across one of Earth's oldest living organisms - the Pando aspen clone - to understand how mutations accumulate and spread in long-lived clonal organisms. Our results were…surprising. 1/30
This story started 5y ago with my lab. Spearheaded by fearless 1st authors @theopi and Olivia Leland. Theopi is now a PhD student at @BrownUniversity. Olivia is a physics PhD student at @BrandeisU, a self-taught biologist, and made us love soft matter. A (very long) thread (1/24)
Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea biorxiv.org/cgi/content/sh… #biorxiv_cellbio
New Preprint Alert! We uncovered how Mg²⁺ depletion by fungi drives P. aeruginosa to evolve novel colistin resistance mechanisms! Check out the details here 👉 [biorxiv.org/content/10.110…]
If you are interested in a graduate degree in Microbiology & Infectious Diseases, come visit us during our zoom session with our program directors, Monday November 11, 6-7pm. Scan below or register here: forms.gle/UcNyAkuS4tYW7c…
Finally, the preprint on my postdoc work from the past 3 years! With mentorship from @PaulTurnerLab and @EmonetLab, I developed a microscopic technique to measure attachment of viruses #phages to bacterial cells @YalePhage @QbioYale . biorxiv.org/content/10.110…
Building and operating flagella consumes ~10% of cellular energy in E. coli. Our work shows there is a mutational cost to high energy consumption and begs the question: did the innovation of a functional flagellum impact the rate of bacterial evolution? doi.org/10.1073/pnas.2…
Cool. We found motility was required for IS5 mutations that activate flhDC )(nature.com/articles/ismej…).
Excited to share our latest manuscript in which we analyzed 10,000 Salmonella genomes, identifying 128 T6SS effectors, including 45 new toxin domains (STox). We also characterized STox15, a lipid-targeting NlpC/P60 member. #Salmonella #T6SS biorxiv.org/content/10.110…
Latest preprint from our lab led by grad student @cassidyprints and her undergrad mentee @IsabellaNLin. She examines conservation and features of the programmed ribosomal frameshift in prfB. Presented by Cassidy at #GRC stress! biorxiv.org/content/10.110…
Clustering of rRNA operons in E. coli is disrupted by σH biorxiv.org/cgi/content/sh… #biorxiv_micrbio
We are excited to share our new study led by @SarSarela (now GL @itqbnova) & Michael Kuhn! By comparing the effects of 30 drugs on a 32-species synthetic community and community members in isolation, communal behaviors emerged in 26% of all cases! Link: cell.com/cell/fulltext/…
My take on sobering new projections of deaths due to #AMR & what we can do to avert them. #superbugs #phage #phagetherapy #vaccines #WASH #antibiotics cnn.com/2024/09/16/hea…
Our work @NCIResearchCtr on how interspecies surfactants facilitate emergent surface spreading in #Paeruginosa by @Delayna_W and @zanyzarr is now out in @JBacteriology @ASMicrobiology ! journals.asm.org/doi/10.1128/jb…
New year, new preprint from our lab @NCIResearchCtr ! Our study co-led by postbac @Delayna_W and postdoc @zanyzarr describes how Pseudomonas aeruginosa exhibits emergent motility in the presence of interkingdom surfactants. See this thread for details.
Postdoctoral Fellow in Microbial Genetics or Genomics, UTHealth Houston @necrosignaling Join us in our multidisciplinary research #genetics, #genomics, #molbio, #evolution, #systems, #bigdata, & #mathematicalmodeling jobrxiv.org/job/university… #antibiot...
Do microbes have memory? Read more in this ASM article highlighting work done by Souvik @necrosignaling in the Harshey lab. asm.org/Articles/2024/…