Alexander Bates
@as_bates
#neuroscience #connectomics #natverse @harvardmed w/ @RachelIreneWils. Past: @MRC_LMB w/ @gsxej, @CamZoology, @flyconnectome. Distant past: @uclnpp. http://asbates.com
The fly has a full #connectome, basically a directed + weighted graph. But what are its connection ‘signs’, excitatory/inhibitory? We move towards this answer, predicting transmitters from EM! w/@BobQubit, vid @amyneurons, 1/n Published @CellCellPress: cell.com/cell/fulltext/…
Researchers have reconstructed the complete wiring diagram, or connectome, of the fruit fly’s adult brain—a feat akin to mapping all the buildings, avenues, and streets in a complex city. bit.ly/4hc6BmO @NewsfromScience
covercovercovercovercovercovercovercovercovercovercover this is terrifically exciting (Also please dw, the central dogma is still very much intact, this is just a bit of a funky spin on it)
The central dogma of molecular biology states that genetic information flows from DNA and RNA to protein, with reverse transcription converting RNA to DNA. In the pursuit of understanding how bacteria defend themselves from viral infection, two groups have found alternative…
Thrilled that our papers mapping and analyzing the connectome of the complete brain adult fruit fly, including our work with @RunzheYang characterizing the network properties of the brain, have been published at @Nature!
Explore the network statistics of the Drosophila brain! Lin et al. characterize the statistical and topological properties of the whole-brain network, revealing the interconnected and highly recurrent structure of the brain. nature.com/articles/s4158…
Nature research paper: Whole-brain annotation and multi-connectome cell typing of Drosophila go.nature.com/4dNAkjf
Had a great time presenting my work at #SfN today. Thank you so much everyone that came by for the inspiring discussions!
Starting soon: FlyWire Live at the Tools, Tech, and Theory BRAIN Initiative Social at #sfn24 Location: maps.app.goo.gl/PZLrucq34QTjtD… Image features neurons colored by neurotransmitter inspired by this paper from @BobQubit @as_bates et al cell.com/cell/fulltext/…
What an extraordinary achievement! Congratulations to everyone involved.
Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to @sdorkenw and Philipp Schlegel, first authors of the connectome papers, @MurthyLab @SebastianSeung for establishing #flywire to make this possible and @dddavi for birthing this dataset.
Volume EM baby! Making waves in the actual proper news! bbc.co.uk/news/articles/…
Some of the Zetta team members produced this automatic reconstruction over 5 years ago. Thanks to @FlyWireNews and collaborators for all the edits and annotations that polished this into a scientific masterpiece!
Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today
Nature research paper: Neuronal wiring diagram of an adult brain FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters go.nature.com/3YaEqw3
Brain of fly to shed light on human thought process bbc.in/3zM7LEH
If you've seen the @FlyWireNews Fly #Connectome images making the rounds and wondering what all the fuss is about, this video is for you. A #scivis primer that covers some essential #neuroscience, context for this historic moment, and the challenge ahead youtu.be/VPaxhoRgqgU
If you are interested in an overview of the special issue, you can start with this feature, written by me with amazing graphics from our team as well as the @FlyWireNews team (let's be real, you should go for the cool graphics and reconstructed neurons) nature.com/immersive/d428…
OK gotta retweet this one. Thanks Greg & right back at you. It’s been a journey!
Typically understated from my friend, collaborator and co-author, Davi Bock. A visionary scientist who set something great in motion 10y ago.
An astonishing *seven* open access papers in @nature tonight describing the structure and function of the Drosophila brain and its 140,000 neurons. Amazing work by dozens of researchers in the FlyWire consortium. Congratulations all! nature.com/nature/volumes…
Brain of fly to shed light on human thought process bbc.in/4ePnhPc
What an amazing time for neuroscience!! We are proud to be part of this great adventure. @Philip_Shiu @Andrew_M_Seeds @GabriellaSterne @FlyWireNews
Nature research paper: A Drosophila computational brain model reveals sensorimotor processing go.nature.com/3ZNPG3R
Huge congratulations!
Incredibly proud and grateful to be part of the #FlyWire team that made this happen. This was an immensely collaborative project - on every level from early open data sharing, to tool building, to analysis - over many years, across many institutions. It's been a fantastic journey
Just in case you’ve missed the news about the fly connectome. @dddavi and co’s volume fully annotated by @FlyWireNews and so many people.
Zoom into the #flywire fly brain courtesy of another of Philipp Schlegel's (@flyconnectome @CamZoology @MRC_LMB) amazing 3D sequences. Then read his piece on the flyconnecto.me blog to find out more about how the #connectome became a reality flyconnecto.me/2024/10/02/fly….
One discussion #onhere (sometimes healthy, often not) is what is the point of these big resources? The FlyWire issue also has papers that *use* the resource. These papers represent significant discoveries and also illustrate how the resource is likely to be used in the future 🧵