Matthew Howard

Happy New Year! Excited to share the final version of our work where we combine deep mutational scanning, cryo-EM, and molecular dynamics to further resolve the mechanisms of pH sensing in GPCRs. 🧵(1/n) cell.com/cell/fulltext/…

Check out our work, where we discover how receptor GPCR senses pH! We develop foundational GPCR DMS tech dev + structural bio that will have impact across historically intractable receptor systems! Led by brilliant PhD student @matthewkhoward and Nick Hoppe w/ @AashishManglik!

Thanks for the invite! Excited to share some of our recent work tomorrow 😀

Amazing study--one of two on proton sensing receptors @CellCellPress Molecular basis of proton sensing by G protein-coupled receptors: Cell cell.com/cell/fulltext/…

Check out our latest research by @MNaghipourfar and others in our team on building language models of coding sequence. In this preprint, we introduce cdsFM, a suite of codon-resolution language models!👇 biorxiv.org/content/10.110…

A Suite of Foundation Models Captures the Contextual Interplay Between Codons @arcinstitute 1. This paper introduces cdsFM, a suite of codon-resolution large language models that include EnCodon and DeCodon models, designed to understand the contextual impact of synonymous…

📢#GPCR ECIs, mark your calendar for the next Transatlantic GPCR Symposium! The event will happen on September 5-6th, 2024 and the registration is already open. The event will host two excellent keynote speakers, Dr. Maria Marti-Solao and Dr. Aashish Manglik. So, don't miss it!