Matt Mandel
@matthewjmandel
investor @usv | ordinary reasoning rendered persistent
Bullish on the philosopher-builders
Every builder's first duty is philosophical: to decide what they should build for. AI is beginning to decide what ideas reach your mind—your next action, your next job, your next relationship. It will tempt you to outsource your thinking in ways you’ve never been tempted before.…
So Google paid billions of dollars to license technology that another company is acquiring? How does that work
I'm excited to share that my Recent Case Comment was published in the June issue of the Harvard Law Review! I wrote about how courts can navigate the administrative law questions that arise as Presidents become increasingly involved in agency action.
Let’s gooo!!
BIG news! @ENERGY has just picked Radiant to test at @INL next year - the first new reactor design tested there in almost 50 years.
TIL Vimeo was started a year before YouTube as a CollegeHumor skunkworks project Good example of new infrastructure being developed out of necessity by app-level innovators (a phenomenon @nickgrossman and @thedanigrant dubbed “the myth of the infrastructure phase”)
AMA with @bryan_johnson Micro plastic reduction (@trevor_klee), Pareto frontier of blood testing (@RobbyWade6, @kenneth_lou), allergen reduction (@EvanZhao6), scientific leveraged trading (@benjileibo), aggregating all data (@kubla), solar-powered wearables (@oldestasian)…
Great research day from @shelbynewsad An idea that stuck with me was reformulating over the counter supplements to feed the microbiome to then produce the therapeutic molecule of interest That way the drug can be accessed as immediately, easily, and cheaply as supplements
Shoutout to @bryan_johnson for answering my question about microplastics at the @usv Biohacking Demo Day Had a ton of fun and met lots of founders doing cool shit at the edge. Thanks for organizing @matthewjmandel @CompoundVC !
Sorkin’s gonna over-rotate on making sure no one leaves this inspired by Zuck isn’t he
‘The Social Network Part II’ is officially in development, with Aaron Sorkin returning—this time as director.
Shoutout to @bryan_johnson for answering my question about microplastics at the @usv Biohacking Demo Day Had a ton of fun and met lots of founders doing cool shit at the edge. Thanks for organizing @matthewjmandel @CompoundVC !
This was so incredibly fun– thanks to everyone who came out and made today such a mindblowing experience And special thanks to all of our presenters: @benjileibo / Pump Science @trevor_klee / NeutraOat @kubla / Fulcra @EvanZhao6 / Pacagen @RobbyWade6 / Rythm @oldestasian /…
In the fall, we hosted an incredible Biohacker Research Day with our friends at @CompoundVC. Since then, we've felt the field accelerating. We've been amazed by the talent coming in and the truly mind-blowing things people are working on In that spirit, we were inspired to…
This event was a highlight of the last month. Thank you to @usv @matthewjmandel @usvlibrarian for hosting.
Haven’t been to an event this exciting in a long time… 🗽Biohacking Demo Day 2.0: @usv x @CompoundVC in NYC The future is here, you just have to go out and build it. Thanks for organising @shelbynewsad @matthewjmandel 🧬🚀
Haven’t been to an event this exciting in a long time… 🗽Biohacking Demo Day 2.0: @usv x @CompoundVC in NYC The future is here, you just have to go out and build it. Thanks for organising @shelbynewsad @matthewjmandel 🧬🚀
Is AI progress studies’ killer use case
The rise of nuclear weapons accelerated game theory's development as a way to help society reason about their proliferation and use Today, no one knows how to respond to AI, in part because we don't know how quickly it's progressing The titotal / AI 2027 exchange really makes…
The foundation model war is a fascinating case study in what matters in a leader Sam is a great company builder and communicator but never did AI research. Dario was a leading AI researcher but hadn't led an org before Anthropic As Meta reorganizes their AI efforts around Alex…
The rise of nuclear weapons accelerated game theory's development as a way to help society reason about their proliferation and use Today, no one knows how to respond to AI, in part because we don't know how quickly it's progressing The titotal / AI 2027 exchange really makes…
On June 24th we’re bringing together leading optimizers, operators, scientists, and all those in between, for a focused discussion around what's next for biohacking. Want to attend? Sign up below.
People don't sufficiently appreciate technology's ability to cut through wicked moral and societal problems Eg it's hard to deny that animal welfare is a huge issue. But outright banning factory farming or animal drug testing is unrealistic. It's hard to look the problem in the…
In (partial) defense of contemporary feuilletonism
Classical civilizations told stories about a great past from which they had fallen After the Industrial Revolution, and especially after WWII, we started telling sci-fi stories about a great future we might build towards People like to bash our media environment for being hyper…
Classical civilizations told stories about a great past from which they had fallen After the Industrial Revolution, and especially after WWII, we started telling sci-fi stories about a great future we might build towards People like to bash our media environment for being hyper…