Mahak Singhal
@mahak906
Junior group leader @ECAS; fascinated to study the role of vascular cells beyond angiogenesis; loves to travel, meet strangers and explore cultures
Wrapping up of @IVBM2024, with the launch of #IVBM2026 in Adelaide.
Want to know how to isolate liver endothelial cells without any prior training? Check our latest work in @CommsBiol, describing a high-throughput perfusion-independent method to isolate liver sinusoidal endothelial cells. Blood vessels rock!!! @EVB_Org rdcu.be/d5C82
Closing 2024 with gratitude and joy to see my scientific family growing. Thanks to them and our brilliant collaborators, we did some crazy science in 2024 with our first paper accepted! Can’t wait for 2025! I wish you all a fantastic holiday and great start to 2025! Thank you!
Just a quick reminder for everyone about our virtual workshop on September 6th, on the pathology of aging: buff.ly/3yKr3K3 This webinar will explore the mechanisms underlying HSC aging, focusing on mitochondrial dysfunction and on the peri-vascular/stromal niche.
It’s happening and I am by excited to witness @IVBM2024. Looking forward to crazy vascular biology!
Please get in touch if working at a junction of circadian and vascular biology excites you!
New PhD opportunity in the lab of Mahak Singhal, within the European Center of Angioscience in Mannheim, DE. More details available at EVBOs Job Opportunities webpage: buff.ly/3wanNX4
Beyond excited to present a perfusion-independent method to isolate liver endothelial cells. Thanks to @ResearchLifesci for supporting the project and a shoutout to the liver community @EVB_Org @vascularbiology for rapid high-throughput LSEC isolation. biorxiv.org/content/10.110…
Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9 | Science Translational Medicine science.org/doi/10.1126/sc…
#Oktoberfest came early at the finale of #LINO23. Embracing #Bayern culture tonight @lindaunobel.
Listening to William Kaelin, describing his personal/scientific journey to his landmark discovery of HIF Prolyl Hydroxylase reaction. #LINO23 @lindaunobel
Opening ceremony at #LINO23, with #climate change, #ArtificialIntelligence & #DiversityandInclusion taking stage for future - Countess Bernadotte. @lindaunobel
Back to one of my favorite places in Germany. This visit is even special, thanks to @UniHeidelberg @CZ_Stiftung for supporting my participation in #LINO23. Looking forward to inspiring discussions at the 72nd Lindau Nobel Laureate Meet.
Almost a year since the inception of my laboratory @UM_Mannheim @UniHeidelberg, it has been a tremendous journey so far. Thanks to the Life Science Alliance @ResearchLifesci for proving an excellent platform! 🙏🏽
Meet the Junior Research Groups in #Angioscience @UniHeidelberg @UM_Mannheim! @mahak906's lab studies circadian vascular signatures mediating interorgan communications and vascular responsiveness to tumor progression and metastasis. More info: bit.ly/3XwDlNA
nature.com/articles/s4225… What do bad eating habits do to our blood vessels? Turns out a poor diet has unique detrimental effects on endothelial cells in different organs. And an improved diet can only partially improve their molecular health. Check out our paper and🧵for dets👇
Spectacular study from Junhao Hu's laboratory (Shanghai) published in @JExpMed identifying in a systems screen of EC-pericyte interactions the NO-soluble guanylate cyclase axis as critical regulator of EC-pericyte crosstalk and lung vascular integrity (rupress.org/jem/article/22…).
A big congratulations to @HellmutAugustin @AshikPari and the whole team. This 8 years long story is just starting point of great translational chapter.
Felcht, @HellmutAugustin et al @UniHeidelberg identify proteolysis of ANGPTL4 as a molecular switch converting a locally protumorigenic molecule into a systemically acting antitumorigenic molecule. N-ANGPTL4 acts an antimetastatic therapeutic agent bit.ly/3syxdGJ
Great insights into liver vasculature during embryonic and postnatal development! Congratulations to @jmgsalinero @RafiiShahin and the whole team! 👏🏼🍾
Felcht, @HellmutAugustin et al @UniHeidelberg identify proteolysis of ANGPTL4 as a molecular switch converting a locally protumorigenic molecule into a systemically acting antitumorigenic molecule. N-ANGPTL4 acts an antimetastatic therapeutic agent bit.ly/3syxdGJ
Congratulations to the whole team, @greenwoodjohn @stephenemoss! Great mechanistic insights into the upstream regulation of LRG1 expression --> rdcu.be/cJJJn
Felcht, @HellmutAugustin et al @UniHeidelberg identify proteolysis of ANGPTL4 as a molecular switch converting a locally protumorigenic molecule into a systemically acting antitumorigenic molecule. N-ANGPTL4 acts an antimetastatic therapeutic agent bit.ly/3syxdGJ
We are HIRING! Looking for multiple PhD/Postdoc to join our lab to study cardiomyocyte polyploidy. Our lab is part of the rapidly expanding cardiovascular research program @UniHeidelberg (with three other new junior groups). DM me if interested. Please RT.
Open positions at all scientific levels! Please feel free to connect and spread the word - WE ARE HIRING!!!👇
Vascular research @UniHeidelberg continues to grow. We got new money & need more manpower: Graduate Students, Postdocs, Scientific Manager, Adm. Support. Augustin lab is recruiting (see below), but also junior groups "Ploidy & OrganPhysiology" & "AngioRhythms in Health & Disease"