Jingli Cao Lab
@lab_cao
Developmental biologist @WeillCornell, using #zebrafish to study heart development and regeneration. @cao-lab.bsky.social
New lab preprint! We did a giant genetic screen for factors that help cells to divide into more than 2 (as can occur in cancer). Our top hit is an unnamed fly gene that has a human counterpart which is targeted by an FDA-approved drug for epilepsy. biorxiv.org/content/10.110…
Super excited to share that our manuscript is finally OUT @CellSystems!!🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. cell.com/cell-systems/f…🧵(1/)
Congratulations @ishahjain and team on this amazing work! HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity: Cell cell.com/cell/fulltext/…
Paper alert🐟! Thrilled to share that our latest study “BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress” nature.com/articles/s4146… is now live in @NatureComms. We show how BMP alleviates this stress via a conserved mechanism in mammals🐭
Excited to share our latest article. 7 years ago my then 9 year old son was diagnosed with K210del DCM. With the help of my colleagues @Joseph_C_Wu, @sadayappanlab and Enzo Porrello we identified an FDA approved drug that corrects the mutation. JCI - An FDA-approved drug…
🚨We are hiring!🚨 We have postdoctoral positions available! If you're passionate about studying cardiac regeneration and development, join our team in vibrant and beautiful Montreal! Please help spread the word 🫶 For more details see here research.chusj.org/RECHERCHE/fi...
report on myocardial patch in a human out in @Nature rdcu.be/d72c2
🚨 We’re hiring a Postdoctoral Fellow to study heart development/regeneration using zebrafish 🐟 & human cardioids ❤️! If you're passionate about stem cell biology, tissue regeneration, heart disease/repair, email me! 🔗 More info: caolab.net
New study from us: elifesciences.org/articles/98661 showing new functions for the fibroblast growth factor homologous factor (FHF) FGF13 in neurons. The roles for FHFs continue to expand! Author Susan Lin co-mentored by @RajadhyakshaLab
The outer ear is a mammalian innovation but where did it come from? In our study in @Nature, @MathiThiru95 and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. nature.com/articles/s4158… 1/n
Well done! 🎉
Excited to share this article, where we highlight the possibility that dysregulation of genes via transcriptional adaptation, an mRNA feedback loop, may play a role in some dominant diseases. @StainierLab A new hypothesis to explain disease dominance sciencedirect.com/science/articl…
🚨Why can’t mammals regenerate legs or arms like frog tadpoles or salamanders? Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing 🔗biorxiv.org/content/10.110… Happy New Year, everyone! 🎉 🐭 vs 🐸 #evodevo #regenerative #cellbio 🧵👇
We are thrilled to share our new single-cell foundation model, Tabula (preprint: biorxiv.org/content/10.110…; package: github.com/aristoteleo/ta…)—a privacy-preserving predictive foundation model for single-cell transcriptomics, leveraging federated learning and tabular modeling. Over…
Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon
🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting.. Check it out here: biorxiv.org/content/10.110… #Genomics #Epigenetics
Happy to publish our collaboration with Diane Mathis on the conservation of thymic mimetic cells in zebrafish, mice and humans. authors.elsevier.com/c/1kL0e3qNrUxu…
Excited to share this collaborative work with @Hadhjantonakis and @dana_peer led by @Vid_ur reporting drastically different interconversion efficiencies between ESC and XEN, unique trajectories mimicking in vivo states, and key plasticity barriers. cell.com/developmental-…
Woohoo! Our latest preprint, from @Madhura0327 Nijsure, is out today @biorxivpreprint! YAP regulates periosteal expansion in fracture repair. biorxiv.org/content/10.110…
I am delighted to share our new study published in @NatureComms in which we uncover a common mechanism by which collagen signaling and matrix stiffness regulate stem cell multipotency in glandular epithelia. nature.com/articles/s4146…
iFlpMosaics are now published @naturemethods. A compendium of novel genetic tools and related methods for inducing and analysing genetic mosaics in a high-throughput manner. nature.com/articles/s4159… Tweetorial 👇
Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration: Cell cell.com/cell/fulltext/…