Calì_Lab
@lab_cali
Tito Calì lab @UniPadova, Full Professor @dsb_unipd. Organelle Contacts, Neurodegeneration. SPLICS and split-FPs based reporters. @[email protected]
Group photo! 👇 👇 👇 👇 👇 Alberto Elena Lucia Flavia Jessica De Covallero Poggio Barazzuol Giamogante Almeida R.
#Throwback REVIEW | L Ferrucci, D D’Amico et al Mitophagy in human health, ageing and disease nature.com/articles/s4225…
Phase separation of a PKA type I regulatory subunit regulates β-cell function through cAMP compartmentalization: journals.plos.org/plosbiology/ar…
A mutual co-recognition mechanism ensures the proper assembly of heterotrimeric kinesin-2 for intraflagellar transport | Nature Communications nature.com/articles/s4146…
Learning the sequence code of protein expression in human immune cells | Science Advances science.org/doi/10.1126/sc…
1/ 🚨 Our new paper is online in @Nature ! As its first author, I’m enthusiastic to finally share it with you all!🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 nature.com/articles/s4158… @OxfordDPAG 🧵👇
18/ @lab_cali P. Hasenhuetl, R. Klemm, @VanMSavage and E. Vrontou for helpful discussions; @VVyazovskiy and @OxNeuro community for discussions on sleep, above and beyond this work;
Borisyuk, Kaganovich, Amen et al. (@EPFL_en @unisouthampton) show that PKC promotes peroxisome-ER interactions and #peroxisome formation. hubs.la/Q03y2Cm30 ▶️ See video summary of the study by Howman: hubs.la/Q03y2Gk20 #ER_literature
GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function | bioRxiv biorxiv.org/content/10.110…
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in @NatMetabolism, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s4225… 1/n
In families with several children of the same sex, the odds of having another baby of that sex are higher than of having one of the opposite sex go.nature.com/4kZr1jO
🧠💤 Mitochondrial origins of the pressure to sleep. This is so cool—sleep deprivation increases ER–mito contacts (thanks SPLICS! 🙏➡️🔆⬅️). Congrats to the team! Turns out your organelles need rest too. 😴 Mind your contacts if you want to count sheep. 📄 nature.com/articles/s4158…
BRD4 acts as a pH sensor to tune inflammation bit.ly/3IOIyNU
ER-endosome contacts generate a local environment promoting phagophore formation dlvr.it/TLvlHV
New online! Conformational plasticity of a BiP–GRP94 chaperone complex bit.ly/44NLhig
Call for Content: Don't forget to submit to Biology Direct's new Collection 'Evolution of prokaryote virus defense'! Guest Edited by Nash Rochman, Tito Calì and Daniele Marcoccia @lab_cali biomedcentral.com/collections/ep…
Call for Content: Don't forget to submit to Biology Direct's new Collection 'Evolution of prokaryote virus defense'! Guest Edited by Nash Rochman, Tito Calì and Daniele Marcoccia @lab_cali biomedcentral.com/collections/ep…
The molecular basis of tricalbin-mediated membrane contact site organization in cells biorxiv.org/content/10.110… #biorxiv_cellbio
P4-ATPases control phosphoinositide membrane asymmetry and neomycin resistance | Nature Cell Biology nature.com/articles/s4155…