Joseph Kreitz
@kreitz_joseph
PhD student in bioengineering at MIT.
Excited to share our new paper, out today in @Nature! We showed that a PVC (basically a 100nm molecular syringe) can be re-wired to deliver proteins into human cells. Thanks to my advisor, @zhangf, and my amazing co-authors at the @broadinstitute nature.com/articles/s4158…
Appreciate the feature @GrinsteinJ!
Discovered in parasitic bacteria, contractile injection systems have been redesigned by @zhangf, @kreitz_joseph, and colleagues to target human cells with protein payloads and have possible applications in #GeneTherapy, #cancer therapy, and biocontrol. Feature by @GrinsteinJ:…
Bacterial molecular syringe for drug delivery. Lu & Cai highlight work of @kreitz_joseph @zhangf @Nature reporting syringe-like protein delivery vector engineered from natural endosymbiotic #bacteria for potential therapeutic & human use. cell.com/cell-host-micr…
Podcast fans, check out this episode of @NaturePodcast highlighting the recent news from @kreitz_joseph, @zhangf and team on bacterial syringes! 🎧 Bacterial ‘syringes’ could inject drugs directly into human cells go.nature.com/3zCclBH
This week on the Nature Podcast: Repurposing a microbial system to deliver molecules directly into cells go.nature.com/3JXZqyF
Delivery of therapeutic molecules is a major bottleneck for treating a wide range of diseases. Today we describe a new modality for delivering proteins based on an engineered contractile injection system @nature nature.com/articles/s4158…
Hot off the press 🔥 @Nature A bacterial contractile injection system can be used to deliver a range of proteins to human cells and mice 💉🦠 by @zhangf & co nature.com/articles/s4158…
Researchers have hijacked a molecular ‘syringe’ that some viruses and bacteria use to infect their hosts, and put it to work delivering potentially therapeutic proteins into human cells go.nature.com/3KjzvDg
Researchers have harnessed a natural bacterial system to develop a new programmable protein delivery approach that works in human cells and animals. The system could potentially be a safe and efficient way to deliver gene therapies and cancer therapies. broad.io/eCISsnews
Researchers @broadinstitute + @mcgovernmit have engineered a molecular syringe to deliver a range of useful proteins -- including ones for gene editing -- to human and mouse cells. Summary 👇 + paper by @zhangf + @kreitz_joseph @Nature mcgovern.mit.edu/2023/03/29/279…
Today we are sharing a research protocol for SHERLOCK-based COVID-19 #coronavirus detection, and hope it will help others who are working to combat the outbreak. We will continue to update this as we make further progress: static1.squarespace.com/static/5b7c640…