John Fryer, PhD
@johnthefryer
Professor, Director of Center for Accelerated Nanotherapeutics at Translational Genomics Research Institute (TGen), part of City of Hope. Views my own. he/him
Hugely important work from @zenbrainest that opens new doors (and immensely complicates the picture!) The polypharmacology of psychedelics reveals multiple targets for potential therapeutics: Neuron cell.com/neuron/abstrac…
Makes you wonder what they’re measuring/publishing…
Another comparison between the Olink and SomaScan proteomics assays in 3976 plasma samples from Chinese adults. Whatever the two platforms measure is not the same. The median correlation across 1,694 1-to-1 matched proteins was only 0.26❗️
It's clear that many do not understand what @NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on…
A fun podcast I did with Karie Dozer on our new Center for Accelerated Nanotherapeutics at TGen where we will harness the power of llamas/alpacas to hopefully treat many maladies. Hope it is accessible to a broad audience. E78:The Power of Nanotherapeutics tgen.org/tgen-talks/epi…
Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal -synapse number and maturation -seizure susceptibility and hippocampal-prefrontal cortex coherence -segregation of inputs into the lateral geniculate nucleus -neuronal and astrocytic gene expression nature.com/articles/s4159…
Potential game changer in how we vaccinate against…everything!
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
Really nice sleuthing from some Northwestern students. I wonder how many of these exist? At least dozens. Agree we need coordinated operations against these. Hidden hydras: uncovering the massive footprint of one paper mill’s operations – Retraction Watch retractionwatch.com/2024/10/01/hid…
@ndosenbach and I founded @TuringMedical to turn two decades of advanced MRI collaboration and friendship into real-world impact. We handed the keys over to the incredible team @TuringMedical and they are bringing that vision to life. Huge congrats on reaching this milestone! 👇🏾
Lots to unpack in this really cool work by @Da_Mesquita_S lab! Not just for brain lymphatics nerds!
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
I feel like the name is close enough that they should name those panda babies Salt and Shaker. Giant panda Ying Ying gives birth to twins : NPR npr.org/2024/08/16/nx-…
This continues to be a problem for research. What’s in a picture? Two decades of image manipulation awareness and action – Retraction Watch retractionwatch.com/2024/08/12/wha…
So sad to hear about the passing of Carl Cotman. He published countless seminal works and is an icon in the field.
If you’ve not seen this paper yet and you do sc/sn-RNAseq, stop and go read it now! Comparative Analysis of Commercial Single-Cell RNA Sequencing Technologies | bioRxiv biorxiv.org/content/10.110…
This was a fun project to collaborate on. We played a small part, but the data is so interesting. Please explore!
Very excited that our astrocyte & microglia circadian atlas preprint is out! Congrats to @Patwsheehan on this awesome work, and thanks to @joeddougherty @darshan1s and especially @johnthefryer! If you study glia, AD, aging, circadian, check it out! @SRBR_Outreach @ResearchSleep
A must read!!!
We analyzed all 5734 of the available WGS samples from The Cancer Genome Atlas, and find far, far smaller numbers of microbes than previous reports that appeared (with great fanfare) in @Nature and @CellCellPress. With @YuchenGe1 et al biorxiv.org/content/10.110…